|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the i(12p) status of a large number of primary sacrococcygeal teratomas in both children and adults, including cases with malignant germ cell tumour elements.
|
27521765 |
2017 |
|
IGHV1-12
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetically, YSTs in infants generally lack i(12p), which is highly characteristic of adult germ cell tumors (GCTs), whereas they frequently show a deletion of 1p36, indicating that the loss of a certain gene(s) in this region is an important event in the pathogenesis of infantile YSTs.
|
12875960 |
2003 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1.
|
12660824 |
2003 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most adult testicular germ cell tumors have a characteristic chromosomal abnormality that is an isochromosome 12p [i(12p)].
|
12072204 |
2002 |
|
IGHV1-12
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Testicular germ cell tumors (GCT) characteristically display two chromosome 12 abnormalities: the isochromosome i(12p) and concomitant deletions of the long arm.
|
11358847 |
2001 |
|
IGHV1-12
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many of the reported karyotypes for adult testicular germ cell tumors (GCTs) are complex and incomplete, although the presence of an isochromosome 12p, i(12p), and gain of 12p material have consistently been found.
|
11463450 |
2001 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Perhaps i(12p) negative cases characterize a subtype of germ cell tumors.
|
9428355 |
1998 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormalities of chromosome 12, however, seem to be recurrent, and among these are small metacentrics assumed to be i(12p) as in other germ cell tumors.
|
8908168 |
1996 |
|
IGHV1-12
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genetic events leading to genesis of testicular germ cell tumors in men appear to be related to aneuploidization followed by the formation of an i(12p) isochromosome, the latter characterizing the preponderant number of testicular germ cell tumors.
|
8627820 |
1996 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization-based approaches for detection of 12p overrepresentation, in particular i(12p), in cell lines of human testicular germ cell tumors of adults.
|
8625271 |
1996 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis.
|
8527395 |
1995 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
This included a germ cell tumor in 12 (30%) patients by the finding of i(12p), increased 12p copy number, or a deletion of the long arm of chromosome 12.
|
7799031 |
1995 |
|
IGHV1-12
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An isochromosome for the short arm of chromosome 12, i(12p), is the most common and characteristic cytogenetic aberration in testicular germ cell tumors.
|
7474934 |
1995 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acute myeloid leukaemia with +i(12p) shortly after treatment of mediastinal germ cell tumour.
|
7803244 |
1994 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
This cell line may be useful in studying the relationship between i(12p) and hematological differentiation of human mediastinal germ cell tumors.
|
8069867 |
1994 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
i(12p) is a highly nonrandom chromosomal marker seen in about 80% of male germ cell tumors with evaluable cytogenetic abnormalities.
|
8308927 |
1994 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosome 12-containing markers, including two dicentrics, in three i(12p)-negative testicular germ cell tumors.
|
7685624 |
1993 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Uniparental origin of i(12p) in human germ cell tumors.
|
7682101 |
1993 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular cytogenetic analysis of i(12p)-negative human male germ cell tumors.
|
7512366 |
1993 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overrepresentation of chromosome 12p sequences and karyotypic evolution in i(12p)-negative testicular germ-cell tumors revealed by fluorescence in situ hybridization.
|
8242603 |
1993 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
A diverse group of gonadal and extragonadal human germ cell tumors (GCT) and GCT-derived cell lines was examined for the presence of an i(12p) marker chromosome and/or other abnormalities involving chromosome 12, especially 12p, by bicolor double fluorescence in situ hybridization (FISH).
|
1330288 |
1992 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
The i(12p) marker chromosome has been found to be a highly nonrandom chromosome abnormality associated with germ cell tumors (GCTs).
|
1384658 |
1992 |
|
IGHV1-12
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No geographic incidence variation was detected for -7 and +21 in ANLL; +8 in MDS; 6q- and +8 in ALL; +12 in chronic lymphocytic leukemia; 6q- in non-Hodgkin's lymphoma (NHL); t(8;14) in Burkitt's lymphoma; t(11;22) in Ewing's sarcoma; i(12p) in germ cell tumors; 1p- in neuroblastoma; structural abnormalities of 3q, 8q, and 9p in PAS; or 3p- in renal cell carcinoma.
|
2069905 |
1991 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytogenetic analysis of germ cell tumors (GCTs) has identified i(12p) as a specific cytogenetic abnormality identified in more than 80% of GCTs, present in all histologies, in primary and metastatic lesions, in testicular and extragonadal presentations, and in ovarian and sex cord stromal tumors.
|
1663944 |
1991 |
|
IGHV1-12
|
0.100 |
Biomarker
|
disease |
BEFREE |
The i(12p) chromosome marker has been shown to be a diagnostic and prognostic marker of human male germ cell tumors (GCTs).
|
1683567 |
1991 |