| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Ovarian theca cell hyperandrogenism in women with polycystic ovary syndrome (PCOS) is compounded by androgen receptor-mediated impairment of estradiol and progesterone negative feedback regulation of episodic luteinizing hormone (LH) release. | 29949806 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Although chronic hyperandrogenism suppresses antral follicular development, a phenomenon often observed in polycystic ovarian syndrome (PCOS), whether and how deregulation of androgen receptor (AR) signaling is involved, is not well understood. | 28860512 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | These findings establish alternative splicing of AR in GCs as the major pathogenic mechanism for hyperandrogenism and abnormal folliculogenesis in PCOS. | 25825716 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | One characteristic of polycystic ovary syndrome (PCOS) is hyperandrogenism, which may be related to the activity of androgen receptor (AR). | 26511871 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | We examined the in vivo and in vitro effects of hyperandrogenism on mononuclear cell (MNC)-derived androgen receptor (AR) status and TNFα release. | 24512496 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The main goal of the present study was to assess the influence of the androgen receptor gene CAG repeat polymorphism on hyperandrogenism and its phenotypical features in patients with polycystic ovary syndrome (PCOS). | 19172534 | 2008 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The clinical manifestations due to hyperandrogenism are influenced by androgen production, androgen metabolism, and androgen receptor activity. | 12880121 | 2003 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. | 12843184 | 2003 |