Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.310 Biomarker disease BEFREE A positive correlation was found between BMPR2 transcripts and hyperandrogenism in FF of PCOS patients. 22825968 2012
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.310 Biomarker disease CTD_human A positive correlation was found between BMPR2 transcripts and hyperandrogenism in FF of PCOS patients. 22825968 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.240 Biomarker disease BEFREE Female prepubertal rats were treated with equine chorionic gonadotropin (eCG) to induce folliculogenesis, together with dehydroepiandrosterone (DHEA) to induce hyperandrogenism and/or PGZ to evaluate PPARG activation. 30508725 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.240 Biomarker disease BEFREE PPARγ are receptors that are probably involved in hyperandrogenism. 21827375 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.240 GeneticVariation disease BEFREE Two hypermethylated CpG sites in the PPARG1 promoter and five hypomethylated CpG sites in the NCOR1 promoter were observed only in HA PCOS women (P < 0.01 to P < 0.0005). 22349439 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.240 Biomarker disease RGD Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition. 20813360 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.240 GeneticVariation disease BEFREE To test the hypothesis that the triad of hyperandrogenism, insulin resistance and acanthosis nigricans (HAIRAN syndrome) in the presence of obesity, also known as type C insulin resistance, is caused by mutations in the gene for peroxisome proliferator activated receptor gamma (PPARgamma), a receptor for the thiazolidinedione drugs that enhance sensitivity to insulin. 10762291 2000
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE The heterozygous carriers of CYP21 mutations are at increased risk of developing clinically evident hyperandrogenism, even though clinical and laboratory characteristics are still underestimated. 31805392 2020
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Women with NC-CAH had significantly lower orgasm scores, a trend toward lower sexual function with higher sexual distress, as well as biochemical evidence of hyperandrogenism (higher dehydroepiandrosterone sulfate and lower SHBG) and a trend toward more clinical signs of hyperandrogenism (hirsutism). 31447379 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE Depending on CYP21A2 genotype, congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to biochemical alterations (including hyperandrogenism, hypocortisolism, and hypoaldosteronism) and a wide spectrum of phenotypic disease manifestation. 31447379 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE A reduction in plasma sex hormone-binding globulin (SHBG), a transport carrier that binds estrogen and androgens and regulates their biological activities, is often used as an indicator of hyperandrogenism in women with PCOS. 31525346 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Nonobese patients with PCOS have adrenal hyperandrogenism as the underlying mechanism while their obese/ insulin-resistant counterparts have low SHBG and hence an increased fraction of free testosterone. 29068242 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE According to reduced sex hormone-binding globulin levels and increased free androgen index in the present study, obesity was linked with hyperandrogenism in female subjects. 30232779 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE The FAI is not a reliable indicator of free T when the SHBG concentration is low and would give misleading information in a large number of women being investigated for hyperandrogenism. 29405348 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE These results were confirmed by a multiple regression analysis model in which adrenal hyperandrogenism was negatively associated with age (<i>P</i> < 0.001) and SHBG concentrations (<i>P</i> = 0.02), but not with any metabolic parameter. 28912337 2017
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE Biological hyperandrogenism was found in the prepubertal CYP21A2 mutation carriers, whereas the four heterozygous girls who were followed long enough to have reached pubertal age presented biological and clinical hyperandrogenism. 20059433 2010
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE Women with hyperandrogenism who are heterozygous CYP21 mutation carriers have normal basal and stimulated 17-OHP levels. 19085698 2009
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 Biomarker disease BEFREE Classical CAH-CYP21 in females allows the study of the effects of hyperandrogenism and chronic glucocorticoid exposure. 19189689 2008
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE It has been hypothesized that carriers of CYP21 mutations are at increased risk of developing clinically evident hyperandrogenism. 16712666 2006
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE In addition, the results support previous findings in which heterozygous CYP21 mutations are associated with symptoms of hyperandrogenism in susceptible individuals. 16028060 2005
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE To our knowledge, these are the first examples of human SHBG variants linked to hyperandrogenism and ovarian dysfunction. 11927624 2002
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Serum androgen, IGFBP-1, and SHBG concentrations; IRS-1 genotypes.Twenty-five of 54 (45%) girls with a history of PP developed hyperinsulinemic ovarian hyperandrogenism at adolescence. 12477526 2002
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease BEFREE Novel mutations in CYP21 detected in individuals with hyperandrogenism. 12050257 2002
Entrez Id: 1589
Gene Symbol: CYP21A2
CYP21A2
0.100 GeneticVariation disease LHGDN Novel mutations in CYP21 detected in individuals with hyperandrogenism. 12050257 2002