Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE When TEAD2 DNA-binding domain was fused with virus protein 16 transcriptional activation domain, it synergized with activated β-catenin to promote HB formation in vivo. 30794805 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE In pediatric patients tested positive for germline mutation of APC gene screening for hepatoblastoma using alpha-fetoprotein and liver ultrasound should be performed. 30836352 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE Transcriptomic analysis showed a strong correlation in gene expression between HB in the Yap1-β-catenin model and HB patient cohorts. 30863496 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE Correction: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development. 31645895 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE Thus, we demonstrate that β-catenin point mutants can also collaborate with YAP1 in HB development, albeit with a distinct molecular profile from the deletion mutant, which may have implications in both biology and therapy. 30794807 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE The Wnt/beta-catenin pathway is one of the major developmental pathways and is believed to play an important role in the pathogenesis of HB and CSC formation. 31547062 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE Here, we investigated the oncogenic properties of 14 different HB- and non-HB-associated β-catenin mutants encoded by Sleeping Beauty vectors following their delivery into the mouse liver by hydrodynamic tail-vein injection. 31597698 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE The β-catenin mutation is frequently observed in hepatoblastoma (HB), but the underlying mechanism by which Wnt/β-catenin signaling induces HB tumor formation is unknown. 31462641 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE Moreover, the role of other signaling pathways in hepatoblastoma in association with Wnt/β-catenin has also been described. 31511432 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE Conflicting reports on the frequency of germline adenomatous polyposis coli (APC) gene mutations in patients with hepatoblastoma (HB) have called into question the clinical value of APC mutation testing on apparently sporadic HB. 29251405 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE Hepatoblastoma may present at birth, and screening for hepatoblastoma in infancy in families with FAP prior to APC mutation testing results may be warranted. 29719120 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE Here, we identify lipocalin 2 (Lcn2) as a target of β-catenin and YAP1 in HB and show that serum Lcn2 values positively correlated with tumor burden. 29920228 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE The Wnt/β-catenin pathway plays a central role in the pathogenesis of most hepatoblastomas (HBs), that is, up to 60-80% carry activating CTNNB1 mutations. 29446530 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 AlteredExpression disease BEFREE Also, niclosamide, a Food and Drug Administration approved antihelminth compound, could effectively inhibit HB cell growth in vitro and in vivo via downregulation of Dvl-2 and β-catenin expression. 29528187 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE In summary, the obtained results imply that an APC mutant together with an X-linked WAS mutant, could lead to HB tumorigenesis by activating Wnt and PLK1 signaling, inhibiting TCR signaling, and reducing the antitumor activity of natural killer and dendritic cells. 30619485 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE Recent studies suggest that activation of Yes-associated protein (YAP) is a major molecular event in HB development, as activated YAP synergizes with mutant β-catenin to promote HB formation in mice (YAP/β-catenin). 29088718 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.700 GeneticVariation disease BEFREE Genomic profiles of a hepatoblastoma from a patient with Beckwith-Wiedemann syndrome with uniparental disomy on chromosome 11p15 and germline mutation of APC and PALB2. 29190888 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE All 3 (100%) mixed epithelial and mesenchymal HBL harbored CTNNB1 mutation. 29079173 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE We detected nuclear β-catenin immunostaining in nearly all untreated HBs, including in fetal and embryonal epithelial components and in mesenchymal elements. 28277286 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE Nuclear β-catenin staining which is significantly common in embryonal elements in HB predicts shorter survival. 28631020 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 AlteredExpression disease BEFREE Nuclear β-catenin expression was significantly associated with membranous epithelial cell adhesion molecule (EpCAM) expression in hepatoblastoma tumor specimens. 28851352 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 AlteredExpression disease BEFREE However, variable survival rates of 60-80% and debilitating chemotherapy sequelae argue for more informed treatment selection, which is not possible by grading the Wnt-β-catenin over activity present in most HBL tumors. 27910913 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 GeneticVariation disease BEFREE To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells of the developing mouse liver. 27734029 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE By contrast, the expression levels of epithelial-cadherin (E-cadherin) and cytosolic accumulation of β-catenin, the two most prominent markers involved in epithelial-mesenchymal transition (EMT), were reduced in liver specimens from patients with metastatic HB compared with that of healthy adjacent control tissue. 25695679 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.700 Biomarker disease BEFREE We transfected the parental HuH6 hepatoblastoma cell line with a doxycycline-inducible shRNA against CTNNB1 (gene coding for β-catenin) to obtain an isogenic cell line pair with or without aberrant β-catenin signaling. 26715116 2015