We studied the PI3K/Akt pathway in myxoid and round cell liposarcomas using a tissue microarray composed of 165 tumors from 111 patients, and mutational analysis of PIK3CA in 44 cases.
An established myxoid liposarcoma avian chorioallantoic membrane model was used for <i>in vivo</i> confirmation of the preclinical <i>in vitro</i> results.<b>Results:</b> A comprehensive subset of myxoid liposarcoma specimens showed elevated expression and phosphorylation levels of various IGF-IR/PI3K/Akt signaling effectors.