Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.220 GeneticVariation disease BEFREE Thyroid growth is driven by the TSH/cAMP/PKA signaling pathway, and it has previously been shown that activation of PKA through genetic ablation of the regulatory subunit Prkar1a (Prkar1a KO) is sufficient to cause follicular thyroid cancer in mouse models. cAMP also activates the Epac proteins and their downstream effectors, Rap1a and Rap1b. 29882482 2018
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.220 GeneticVariation disease BEFREE We developed and characterized mice carrying thyroid-specific double knockout of the Prkar1a and Pten tumor suppressor genes and compared signaling alterations observed in the mouse FTC to the corresponding human tumors. 24512487 2014
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.220 Biomarker disease MGD