×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.800
GeneticVariation
disease
UNIPROT
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.800
Biomarker
disease
HPO
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.800
CausalMutation
disease
CGI
×
Entrez Id:
3481
Gene Symbol:
IGF2
IGF2
0.500
Biomarker
disease
HPO
×
Entrez Id:
4221
Gene Symbol:
MEN1
MEN1
0.420
Biomarker
disease
HPO
×
Entrez Id:
5573
Gene Symbol:
PRKAR1A
PRKAR1A
0.130
Biomarker
disease
HPO
×
Entrez Id:
1028
Gene Symbol:
CDKN1C
CDKN1C
0.120
Biomarker
disease
HPO
×
Entrez Id:
283120
Gene Symbol:
H19
H19
0.110
Biomarker
disease
HPO
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.110
Biomarker
disease
HPO
×
Entrez Id:
3784
Gene Symbol:
KCNQ1
KCNQ1
0.100
Biomarker
disease
HPO
KCNQ1OT1
0.100
Biomarker
disease
HPO
×
Entrez Id:
105259599
Gene Symbol:
H19-ICR
H19-ICR
0.100
Biomarker
disease
HPO
×
Entrez Id:
1027
Gene Symbol:
CDKN1B
CDKN1B
0.100
Biomarker
disease
HPO
×
Entrez Id:
1030
Gene Symbol:
CDKN2B
CDKN2B
0.100
Biomarker
disease
HPO
×
Entrez Id:
1026
Gene Symbol:
CDKN1A
CDKN1A
0.100
Biomarker
disease
HPO
×
Entrez Id:
1031
Gene Symbol:
CDKN2C
CDKN2C
0.100
Biomarker
disease
HPO
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.110
GeneticVariation
disease
BEFREE
One patient with adrenocortical carcinoma had a somatic mutation in the HRAS1 gene in the normal adrenal gland.
2564050
1989
×
Entrez Id:
107648861
Gene Symbol:
DEL11P13
DEL11P13
0.010
GeneticVariation
disease
BEFREE
Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma .
2566168
1989
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.010
GeneticVariation
disease
BEFREE
One patient with adrenocortical carcinoma had a somatic mutation in the HRAS1 gene in the normal adrenal gland.
2564050
1989
×
Entrez Id:
8045
Gene Symbol:
RASSF7
RASSF7
0.010
GeneticVariation
disease
BEFREE
One patient with adrenocortical carcinoma had a somatic mutation in the HRAS1 gene in the normal adrenal gland.
2564050
1989
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
0.330
Biomarker
disease
BEFREE
The finding that multidrug resistance mediated by mdr-1 /Pgp can be reversed by mitotane provides a rational basis for exploring the use of mitotane in combination with natural product chemotherapeutic agents in adrenocortical cancer .
1675220
1991
×
Entrez Id:
23158
Gene Symbol:
TBC1D9
TBC1D9
0.020
Biomarker
disease
BEFREE
The finding that multidrug resistance mediated by mdr-1 /Pgp can be reversed by mitotane provides a rational basis for exploring the use of mitotane in combination with natural product chemotherapeutic agents in adrenocortical cancer .
1675220
1991
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.800
GeneticVariation
disease
BEFREE
Detection of novel germ-line p53 mutations in diverse-cancer-prone families identified by selecting patients with childhood adrenocortical carcinoma .
1569604
1992
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.110
GeneticVariation
disease
BEFREE
Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis.
1351034
1992
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.800
GeneticVariation
disease
BEFREE
These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation.
8509216
1993