Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 AlteredExpression disease BEFREE IGF1R expression levels were significantly higher in pediatric adrenocortical carcinomas, suggesting that IGF1R expression represents a potential prognostic marker in this group of patients. 22019903 2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease BEFREE IGF1R amplification was detected in an adrenocortical carcinoma that was diagnosed in a 46-year-old woman with Cushing's syndrome and virilization. 25110710 2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease BEFREE After 24h, the treatment also decreased the expression of genes related to the steroid biosynthetic process, the protein levels of the steroidogenic acute regulatory protein (STAR), and androgen secretion in cell medium, supporting the role of IGF1R in steroidogenesis of adrenocortical carcinoma cells. 27185872 2016
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 AlteredExpression disease BEFREE It is evident, therefore, that high levels of IGF-II in combination with overexpression of the IGF-I-receptor can provide a significant growth advantage for adrenocortical carcinoma cells and thus contribute to the highly malignant phenotype of this rare type of cancer. 15241731 2004
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease CTD_human Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma. 22407999 2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease BEFREE The molecular characterization of adrenocortical carcinoma has identified dysregulation of the Gap 2/mitosis transition and the insulin-like growth factor 1 receptor signaling cascade as two major pathways for therapeutic development. 21045685 2011
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease BEFREE The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e.IGFII/IGF1R, β-catenin, Wnt, ESR1). 26312764 2015
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.370 Biomarker disease BEFREE We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner. 26131713 2015