Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 Biomarker disease BEFREE The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e.IGFII/IGF1R, β-catenin, Wnt, ESR1). 26312764 2016
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 Biomarker disease BEFREE We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner. 26131713 2016
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 AlteredExpression disease BEFREE We demonstrated amplification and overexpression of IGF1R gene in only one adrenocortical carcinoma, suggesting that these combined events are uncommon. 25110710 2015
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 Biomarker disease CTD_human Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma. 22407999 2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 AlteredExpression disease BEFREE IGF1R expression levels were significantly higher in pediatric adrenocortical carcinomas, suggesting that IGF1R expression represents a potential prognostic marker in this group of patients. 22019903 2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.350 Biomarker disease BEFREE The molecular characterization of adrenocortical carcinoma has identified dysregulation of the Gap 2/mitosis transition and the insulin-like growth factor 1 receptor signaling cascade as two major pathways for therapeutic development. 21045685 2011