COX-2 overexpressed cholangiocarcinoma (CCA) murine cells took up more <i>ortho</i>-[<sup>18</sup>F]fluorocelecoxib than that by usual CCA cells from 10 to 60 minutes post incubation.
The aggressive cholangiocarcinoma (CCA) representing a liver cancer that overexpresses COX-2 enzyme is aimed to be targeted by COX-2 selective boron carrier, fenbufen boronopinacol (FBPin).
Bile from APBDU can significantly promote the proliferation of human cholangiocarcinoma QBC939 cells compared with normal bile (P=0.005) and up-regulated remarkably their COX-2 mRNA expression (P=0.004).