Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE In this study, we determined the frequency of amplification of the HER2 gene in a comprehensive and well-characterized European cholangiocarcinoma cohort encompassing 436 patients including intrahepatic (n = 155), proximal (n = 155) and distal (n = 126) cholangiocarcinoma by strict application of a combined immunohistochemical and in situ hybridization algorithm following the current guidelines for HER2 assessment in gastric cancer. 31805897 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE Cell-surface expression of HER2 was observed in both gallbladder carcinoma and cholangiocarcinoma tissues. 30659304 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 GeneticVariation disease BEFREE Among the newly discovered molecular alterations, targeting FGFR2 fusions, IDH1/2 mutations and HER2 receptors hold great promise for improving the future management of cholangiocarcinoma. 30124336 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Nine patients with gallbladder cancer and five patients with cholangiocarcinoma had received HER2/neu-directed therapy (trastuzumab, lapatinib, or pertuzumab) during the study period. 26022204 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Multiplex immunostaining/tissue cytometry and immunoprecipitation studies showed: 1) BRK co-localized with EGFR and ErbB2/neu; 2) BRK(high)/EGFR(high)-co-expressing CC cells had significantly higher Ki67 labeling and; 3) stronger BRK protein expression was seen in perihilar and distal CC than intrahepatic CC and directly correlated with CC differentiation. 25770659 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Overexpressions of EGFR and HER2 are thought to be prognostic factors of cholangiocarcinoma (CCA). 25181339 2014
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K. 20731018 2010
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Because epidermal growth factor receptor and HER-2/neu antagonists have been successfully used in adenocarcinomas from other sites, their use in cholangiocarcinoma can be potentially beneficial. 20040392 2010
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. 18087285 2008
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease LHGDN Expression of c-erbB-2 proto-oncogene in extrahepatic cholangiocarcinoma and its clinical significance. 17690040 2007
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease LHGDN HER-2/neu protein overexpression by HER-2 gene amplification may occur in human extrahepatic CC and constitute an independent prognostic factor in patients with lymph node metastases. 17322545 2007
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE HER-2/neu protein overexpression by HER-2 gene amplification may occur in human extrahepatic CC and constitute an independent prognostic factor in patients with lymph node metastases. 17322545 2007
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease CTD_human Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. 16818635 2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. 16344070 2005
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease LHGDN The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC. 12143054 2002
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE Moreover c-erbB-2 mRNA was not detected in seven hepatocellular carcinomas examined by Northern blot analysis. c-erbB-2 overexpression is, therefore, unlikely to be contributing to the malignant phenotype in hepatocellular carcinoma and cholangiocarcinoma. 1380026 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Expression of c-myc, c-ras, and c-erbB-2 oncogenes may be used as immunohistochemical markers to distinguish cholangiocarcinoma from nonneoplastic biliary tissues, and may provide useful information concerning the cell biology of tumor differentiation. 2574140 1989