Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE BRAF inhibitors showed activity in BRAF V600E mutated cholangiocarcinomas and pancreatic carcinomas in non-first line settings. 31221175 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 Biomarker disease BEFREE BRAF gene amplifications were demonstrated in intrahepatic CC (4.3%), common bile duct cancer (3.3%), and gallbladder cancer (5%). 27745798 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 Biomarker disease BEFREE (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival. 27203373 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE In biliary tract cancer, reported BRAF mutation rates are highly controversial, ranging from 0 to 33% in adenocarcinoma of the gallbladder and 0 to 22% in cholangiocarcinoma. 24309328 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE Twenty-five mutations were identified in 23 of the 94 cholangiocarcinomas within the following oncogenes: KRAS (n = 12), PIK3CA (n = 5), MET (n = 4), EGFR (n = 1), BRAF (n = 2), and NRAS (n = 1). 23391413 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma, colorectal carcinoma, ovarian cancer, papillary thyroid carcinoma, and cholangiocarcinoma. 23844038 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients. 21051183 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE The novel multi-kinase inhibitor sorafenib potently suppresses the growth of various cancers by inhibiting kinases of wild-type B-Raf, mutant(V559E)B-Raf and C-Raf but its effects on CC remains to be explored. 17266941 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 GeneticVariation disease BEFREE Activating BRAF missense mutations were identified in 15/69 CC (22%) and in one case of tumour surrounding liver. 12692057 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.390 CausalMutation disease CGI