Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate.
The aim of this study was to investigate the genetic polymorphisms in 5, 10-methylenetetrahydrofolate reductase (MTHFR677C/T and 1298A/C) and to evaluate its associations with the risk of Non Hodgkin lymphoma.
Methylenetetrahydrofolate reductaseC677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
This is the first reported case of intracardiac thrombosis with MTHFRA1298C and factor XIII V34L mutations together with granulomatous reaction in non-Hodgkin lymphoma.
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.