Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE As a proof of concept, α-fetoprotein (AFP) was detected as a target, which is a biomarker of liver cancer. 28155925 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE A novel label-free immunosensor based on hyperbranched polyester nanoparticles with nitrite groups (HBPE-NO<sub>2</sub>), which were synthesized through a simple one-step chemical reaction, was first developed for specific detection of α-fetoprotein (AFP), the tumor marker for liver cancer. 28167413 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE Here, to overcome water absorption and enhance the THz biosensing sensitivity, two kinds of THz metamaterials biosensor integrated with microfluidics were fabricated and used to detect the Alpha fetoprotein (AFP) and Glutamine transferase isozymes II (GGT-II) of liver cancer biomarker in early stage. 29180650 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer. 27535982 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE In the study, liver cancer biomarker alpha-fetoprotein (AFP) was used as an assay model, two different antibodies were labeled with SNPs and fluorophore Alexa Fluor 488, respectively. 28436659 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 GeneticVariation disease BEFREE Multivariate analysis revealed that younger age, normal alpha fetoprotein, single site of extra-hepatic disease, local treatment to the primary tumor and surgery to the metastatic disease were associated with better overall survival and liver cancer-specific survival. 28276812 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE In addition, murine α-fetoprotein (mAFP) was expressed throughout and ultrastructural features met the criteria for liver cancer. 29085472 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE Model for end-stage liver disease scores and levels of α-fetoprotein were prognostic factors, independent of Barcelona Clinic Liver Cancer stage. 27521507 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE Even in clinical liver cancer samples, the expression of α-fetoprotein and Jagged1 showed significant correlation, and amplification of the copy number of Jagged1 was associated with Jagged1 mRNA expression and poor survival after liver cancer surgical resection. 27315779 2016
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE Our previous studies indicated that targeted expression of therapeutic BikDD driven by a liver cancer-specific α-fetoprotein promoter/enhancer (eAFP) in the VISA backbone (eAFP-VISA-BikDD) significantly and specifically kills HCC cells in multiple orthotopic animal models. 26247632 2015
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 GeneticVariation disease BEFREE Subgroup analysis among patients with tumor size ≤ 5.0 cm (n=109), patients at Barcelona Clinic Liver Cancer stage 0 or A (n=92), and patients with α-fetoprotein ≤ 20 ng/mL (n=61), the ATAD2-positive groups unfavorably influenced RFS (p=0.008, p=0.009, and p=0.013, respectively). 25687855 2015
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE Effects of AFP-activated PI3K/Akt signaling pathway on cell proliferation of liver cancer. 24425104 2014
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE These results suggest that Alpha-fetoprotein may play a regulatory role on angiogenesis and cell invasion during liver cancer development. 24587407 2014
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE There were significant differences between the two groups in term of alpha-fetoprotein (α-FP) level (p<0.01), tumor size (p<0.01), TNM stage (p<0.01), recurrence incidence (p<0.01) and family history of liver cancer (p<0.01). 23556002 2013
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE We coated replication-deficient (Ad5-CMV/NIS) (CMV is cytomegalovirus) and replication-selective (Ad5-E1/AFP-E3/NIS) adenovirus serotype 5 carrying the hNIS gene with poly(amidoamine) dendrimers generation 5 (PAMAM-G5) in order to investigate transduction efficacy and altered tropism of these coated virus particles by (123)I scintigraphy and to evaluate their therapeutic potential for systemic radiovirotherapy in a liver cancer xenograft mouse model. 23843567 2013
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE The design of Ad.enAFP-E1A-ΔE1B-IL-24 and its potent antitumor effect on liver cancer have not been published previously. 22790965 2012
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE To achieve liver cancer targeting and to improve the safety of the ZD55 vector (a widely-used E1B55KD gene-deleted oncolytic adenoviral vector (OV), we previously constructed), we designed a novel OV named Ad·AFP·D55 that selectively replicates in hepatocellular carcinoma (HCC) cells by replacing the E1A promoter with the liver-cancer specific α-Fetoprotein (AFP) promoter based on the ZD55 vector. 21979578 2012
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE Cancer targeting gene-viro-therapy specific for liver cancer by α-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24. 21835849 2011
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE PEG-PEI/Fe₃O₄ nanomagnetic fluid successfully transfected PEGFP-AFP-hTNFα into HepG2 cells and induced expression of hTNFα gene in the HepG2 cells, thus showing promise as a gene vector for liver cancer gene therapy. 21621154 2011
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE α-Fetoprotein (AFP), which is a serological marker of liver cancer, was used as a model analyte to test STA-AQ in an immunoassay. 21389603 2011
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer. 21216289 2011
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE The expression cassette AFP-HCCS1-WPRE-SV40 was inserted into Ad.SPDD to form Ad.SPDD-HCCS1, enabling us to improve the safety and efficacy of oncolytic-mediated gene therapy for liver cancer. 22040050 2011
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer. 18194454 2008
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 AlteredExpression disease BEFREE To address this hypothesis, we carried out global mRNA expression analysis of 21 liver cancer cell lines that produce varying levels of AFP. 19038010 2008
Entrez Id: 174
Gene Symbol: AFP
AFP
0.100 Biomarker disease BEFREE The serum AFP elevation by the infection of HBV and HCV is one of mechanisms which lead to hepatocarcinogenesis, and the antivirus intervening treatment of hepatitis is significant for the prognosis of liver cancer. 17465484 2007