Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 GeneticVariation disease BEFREE We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity. 31560893 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Immunohistochemical results revealed that STAT3 activation was positively correlated with increased HSD17B4 expression in tumor tissues from patients with liver cancer. 30747222 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Our study suggested that HOAX11-AS could regulate the JAK-STAT signaling pathway by miR-15a-3p/STAT3 axis to promote the progression of liver cancer. 31099097 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The results of the present study highlight the pivotal function of microRNA-543 as an inhibitor in liver cancer cell proliferation by observing JAK2/STAT3/c-Myc/Bcl-2 in liver cancer. 30675310 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Since STAT3 plays a key role in invasion, migration, and metastasis of cancer, we investigated whether ent-sauchinone could exert promising inhibitory effects on the invasion and migration of the metastatic human liver cancer cell line SMMC-7721 in the present study. ent-Sauchinone was extracted from dried herbs of Saururus chinensis (Lour.)Baill. 29495104 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Notably, STAT3 transcription activity, indicated by its phosphorylation on Y705 is heterogeneous in different liver cancer cell lines. 29805309 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Though embryonic liver fodrin (ELF) is a pro-differentiation protein, it was expressed in the CD13 positive liver cancer stem cells along with stem cell markers such as Oct-4 and STAT3. 29630108 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The permanent activation of hepatocellular carcinoma-associated proto-oncogenes such as c-Jun and associated transcription factors including STAT3 by substances released from tissue-trapped schistosome eggs may be important factors contributing to the development of liver cancer in S. mansoni-infected patients. 30053321 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Furthermore, the STAT3-S1PR pathway that has been reported previously to mediate the effect of SphK1 on colorectal cancers was not altered by SphK1 deletion in liver cancer. 29643998 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo. 28187727 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE However, few inhibitors targeting up-streams of STAT3 are available for the therapy of liver cancer. 28430601 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE There is no STAT3 inhibitors approved to be used clinically for the treatment or prevention of liver cancer. 28714512 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. 28810927 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Here, to explore whether 8-bromo-7-methoxychrysin (BrMC) inhibits liver cancer stem-like cell (LCSLC) properties via disrupting STAT3/Twist signaling, we cultured SMMC-7721 cells in vitro, and evaluated the effects of BrMC on the stemness of spheroids by determining the sphere-forming capability and migration. 28369327 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. 29151958 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HIF-1α) by phosphorylating STAT3 (signal transducer and activator of transcription 3) at Y705 (tyrosine 705) as a plausible mechanism for liver cancer cell proliferation. 25661370 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells. 24912675 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer. 25063062 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The negative crosstalk between NF-kappaB and STAT3, which is also evident in human HCC, is a critical regulator of liver cancer development and progression. 20227042 2010
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE One potential mechanism by which HBx can cause liver cancer may involve intracellular distribution and consecutively modulation of the proliferative important STAT/SOCS signaling with upregulation of STAT3. 19321929 2008