Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.010 AlteredExpression disease BEFREE Rhythmic expressions of metabolic detoxification genes, GSTs1 and CYP397A1 displayed similar expression patterns with total GST and P450 enzyme activities in LD and DD conditions, respectively. 31206537 2019
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.010 AlteredExpression disease BEFREE Here, we report, first, circadian expression of clock genes in the lateral habenula (LHb) under constant darkness (DD) condition in wild-type mice which is disturbed in double Per1<sup>-/-</sup>-Per2<sup>Brdm1</sup> clock-mutant mice. 30242505 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.010 AlteredExpression disease BEFREE DD+ patients demonstrated higher levels of carboxyl-terminal telopeptide of collagen type I (P = .04), and trends toward higher interleukin-6 and oxidized low-density lipoprotein levels (P ≤ .08). 31682908 2019
Entrez Id: 133482
Gene Symbol: SLCO6A1
SLCO6A1
0.010 AlteredExpression disease BEFREE Rhythmic expressions of metabolic detoxification genes, GSTs1 and CYP397A1 displayed similar expression patterns with total GST and P450 enzyme activities in LD and DD conditions, respectively. 31206537 2019
Entrez Id: 373156
Gene Symbol: GSTK1
GSTK1
0.010 AlteredExpression disease BEFREE Rhythmic expressions of metabolic detoxification genes, GSTs1 and CYP397A1 displayed similar expression patterns with total GST and P450 enzyme activities in LD and DD conditions, respectively. 31206537 2019
Entrez Id: 8563
Gene Symbol: THOC5
THOC5
0.010 AlteredExpression disease BEFREE Furthermore, RNA high-throughput sequencing (Seq) revealed that THOC5 silencing closely resembled the gene expression changes induced on PDGF (platelet-derived growth factor)-BB/PDGF-DD treatments in cultured VSMCs. 30026254 2018
Entrez Id: 23440
Gene Symbol: OTP
OTP
0.010 Biomarker disease BEFREE Our systematic study of dynamical decoupling (DD) as a function of temperature (at 40, 80 K and RT), spin concentration, deuteration of nitroxide and/or OTP matrix and DD scheme for 1 to 5 refocusing pulses reveals that DD significantly prolongs phase memory times with respect to Hahn echo relaxation at 40 K, which we discuss in an SSE framework. 29261205 2018
Entrez Id: 8863
Gene Symbol: PER3
PER3
0.010 AlteredExpression disease BEFREE Transcript levels of Per1a and Per3 genes showed circadian rhythmic changes under both LL and DD conditions, while those of Cry genes were controlled by light. 28418034 2017
Entrez Id: 1407
Gene Symbol: CRY1
CRY1
0.010 AlteredExpression disease BEFREE However, in vivo, peak expression of per2 and cry1 was shifted 2-4h earlier under DD conditions, and their expression was upregulated in response to short exposures to light when larvae were kept under DD conditions. 28249777 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.010 Biomarker disease BEFREE Instead, rapamycin upregulated EL4 IL2 receptor in vitro and in vivo, facilitating direct DD tumor cell killing. 27737881 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.010 Biomarker disease BEFREE Using mesenchymal stem cells (MSCs) in an in vitro chondrogenesis assay, we found that knockdown of the diastrophic dysplasia (DTD) sulfate transporter (DTDST, also known as SLC26A2), which is required for normal cartilage development, blocked cell condensation and caused a significant reduction in fibronectin matrix. 25146392 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.010 GeneticVariation disease BEFREE Furthermore, stratification of the ALS samples showed that this variation was not associated with increased age of onset in ND and DD patients in comparison to NN patients (p=0.48). 22005552 2012
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
0.010 GeneticVariation disease BEFREE Furthermore, stratification of the ALS samples showed that this variation was not associated with increased age of onset in ND and DD patients in comparison to NN patients (p=0.48). 22005552 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.010 GeneticVariation disease BEFREE There was no interaction between the APOE-epsilon4 allele and the ACE-DD phenotype in the prediction of cognitive decline. 20606435 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.010 GeneticVariation disease BEFREE PTEN mutations were found in 2/39 (5.1%) ASD patients and 2/51 (3.9%) MR/DD patients. 20533527 2010
Entrez Id: 1297
Gene Symbol: COL9A1
COL9A1
0.010 Biomarker disease BEFREE Her phenotype evolved with age into an intermediate phenotype between r-MED and DTD. 18553123 2008
Entrez Id: 1298
Gene Symbol: COL9A2
COL9A2
0.010 Biomarker disease BEFREE Her phenotype evolved with age into an intermediate phenotype between r-MED and DTD. 18553123 2008
Entrez Id: 9469
Gene Symbol: CHST3
CHST3
0.010 Biomarker disease BEFREE Analysis of chondroitin sulfate proteoglycans in dermal fibroblasts showed markedly decreased 6-O-sulfation but enhanced 4-O-sulfation, confirming functional impairment of CHST3 and distinguishing them from diastrophic dysplasia sulphate transporter (DTDST)-deficient cells. 18513679 2008
Entrez Id: 1299
Gene Symbol: COL9A3
COL9A3
0.010 Biomarker disease BEFREE Her phenotype evolved with age into an intermediate phenotype between r-MED and DTD. 18553123 2008
Entrez Id: 6334
Gene Symbol: SCN8A
SCN8A
0.010 Biomarker disease BEFREE Her phenotype evolved with age into an intermediate phenotype between r-MED and DTD. 18553123 2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.010 GeneticVariation disease BEFREE Ten CNR1 markers and 38 ancestry-informative markers were genotyped in 451 healthy control subjects and 550 SD (AD and/or DD) patients (including European Americans [EAs] and African Americans [AAs]). 17509535 2007
Entrez Id: 5741
Gene Symbol: PTH
PTH
0.010 AlteredExpression disease BEFREE Patients with the DD allele (group DD) of ACE gene polymorphism had (1) significantly elevated mean 5-y intact parathyroid hormone levels when compared with the non-DD group (P=.009), and (2) significantly elevated oral and intravenous 5-y cumulative doses of vitamin D. Oral and intravenous 5-y cumulative doses of vitamin D used in group DD patients were significantly higher than those in group I patients (P=.038 and P=.037, respectively). 17142213 2007
Entrez Id: 9060
Gene Symbol: PAPSS2
PAPSS2
0.010 GeneticVariation disease BEFREE Two sulfation-related genes have been reported as the causal genes of severe chondrodysplasias: mutations in PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) cause spondylo-epimetaphyseal dysplasia (SEMD), and mutations in SLC26A2 (solute carrier family 26, member 2) cause diastrophic dysplasia. 11558903 2001
Entrez Id: 375611
Gene Symbol: SLC26A5
SLC26A5
0.010 Biomarker disease BEFREE In addition to sat-1 and prestin, which were cloned from rat and gerbil, respectively, three human members have been identified and associated with specific genetic diseases (DTD, diastrophic dysplasia; CLD, congenital chloride diarrhea; PDS, Pendred syndrome). 11247665 2001
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.010 Biomarker disease BEFREE A significant positive correlation coefficient between the SBP and logUAE slopes was observed for the DD patients (r=0.57, P<0.0001) but was absent in patients carrying the I allele (II r=-0.03, P=NS; I/D r=0.01, P=NS). 10642347 2000