Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 AlteredExpression disease LHGDN POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT. 18057378 2007
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 AlteredExpression disease BEFREE POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT. 18057378 2007
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1 		0.010 AlteredExpression disease BEFREE NeuroD1 mRNA levels were less in CD than those in NFT, but almost comparable between SCA and NFT. 18057378 2007
Entrez Id: 3066
Gene Symbol: HDAC2
HDAC2 		0.020 AlteredExpression disease BEFREE HDAC2 mRNA levels in CD and SCA were lower than those in NFT. 18057378 2007
Entrez Id: 2693
Gene Symbol: GHSR
GHSR 		0.020 Biomarker disease BEFREE GHSR-1a expression was higher in patients (CD and EAS) presenting in vivo response to GHRP-6. 18426818 2008
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH-secreting pituitary tumor samples were obtained during transphenoidal surgery from patients with Cushing disease and normal pituitary tissues from autopsies. 18840638 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.030 AlteredExpression disease BEFREE CDKN2A gene expression was about fourfold greater in CD than in SCA and NFA. 20616110 2010
Entrez Id: 5081
Gene Symbol: PAX7
PAX7 		0.010 AlteredExpression disease BEFREE Pax7 expression is conserved in human and dog melanotropes and defines two subtypes of pituitary adenomas causing Cushing's disease. 23070814 2012
Entrez Id: 5111
Gene Symbol: PCNA
PCNA 		0.010 Biomarker disease BEFREE Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. 25942479 2015
Entrez Id: 1153
Gene Symbol: CIRBP
CIRBP 		0.010 Biomarker disease BEFREE CIRP appears to play a critical tumorigenesis function in Cushing's disease and its expression might be a useful biomarker for tumor recurrence. 26824322 2016
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH = adrenocorticotrophic hormone; BA = bilateral adrenalectomy; CBG = cabergoline; CD = Cushing disease; CV = coefficient of variation; DXM = dexamethasone; IQR = interquartile range; RT = radiation therapy; SRS = stereotactic radiosurgery; TSS = transsphenoidal surgery; UFC = urinary free cortisol; ULN = upper limit of normal. 28332874 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. 28382019 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.060 Biomarker disease BEFREE EGFR tyrosine kinase inhibitor (TKI) therapy has emerged as a potential new therapeutic approach for patients with aggressive prolactinomas and Cushing disease. 28520590 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH-secreting pulmonary carcinoids, like the corticotroph adenomas causing Cushing's disease, are often small and difficult to detect, and patients present with a gradual onset of the classical signs and symptoms of Cushing's syndrome, indistinguishable from the presentation of Cushing's disease. 29754641 2018
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone; BRG1 = Brahma-related gene 1; CABLES1 = CDK5 and ABL1 enzyme substrate 1; CD = Cushing disease; CNC = Carney complex; DICER1 = cytoplasmic endoribonuclease III; EGFR = epidermal growth factor receptor; GR = glucocorticoid receptor; IL = interleukin; MEN = multiple endocrine neoplasia; miRNA = microRNA; POMC = proopiomelanocortin; SSTR = somatostatin receptor; USP8 = ubiquitin-specific protease 8. 30084690 2018
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1 		0.020 Biomarker disease BEFREE CYP11B1 is a promising drug target to manage Cushing's disease, a disorder arising from excessive cortisol production. 30425102 2019
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.400 Biomarker disease BEFREE Adrenocorticotropic hormone (ACTH)-secreting adenomas account for Cushing's disease (CD) which is the most common form of ACTH-dependent Cushing's syndrome (CS). 30488233 2019
Entrez Id: 84654
Gene Symbol: SPZ1
SPZ1 		0.010 AlteredExpression disease BEFREE TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease. 31016850 2019
Entrez Id: 203074
Gene Symbol: PRSS55
PRSS55 		0.010 AlteredExpression disease BEFREE TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease. 31016850 2019
Entrez Id: 7180
Gene Symbol: CRISP2
CRISP2 		0.010 AlteredExpression disease BEFREE TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease. 31016850 2019
Entrez Id: 9101
Gene Symbol: USP8
USP8 		0.800 Biomarker disease BEFREE USP-8 may be a new treatment target in Cushing's disease. 31666445 2020
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.010 AlteredExpression disease BEFREE CHEK2 mRNA expression in the CD group was significantly higher than that in the acromegaly group (p = 0.012). 31828584 2020
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		0.010 GeneticVariation disease BEFREE A 51-year-old man with LS (MSH2 mutation) and a history of colon carcinoma presented with severe Cushing disease and a locally aggressive pituitary tumor. 28938458 2017
Entrez Id: 4221
Gene Symbol: MEN1
MEN1 		0.040 Biomarker disease BEFREE A 54-year-old man with Cushing disease had MEN1-driven Crooke cell and gonadotroph tumors. 30215160 2018