Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrP<sup>C</sup>) prevents development of memory deficits in APP<sub>swe</sub>/PS1ΔE9 mice, a model of familial AD.
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.
Therefore, we also investigated the dynamic of other protein markers involved in cognition and memory impairment such as metabotropic glutamate receptor 5 (mGluR5), ionotropic NMDA receptor (NMDAR2B), prion protein (PrPc) and amyloid precursor protein (APP), whose activity depends on membrane lipid organization.