| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | phenotype | BEFREE | The behavioral tests were performed over an experimental period of 0.5-8 h. Both free and nanoencapsulated DIM reduced the mechanical hypernociception induced by CFA, mitigated nociceptive behavior of formalin-induced neurogenic and inflammatory pain and increased paw withdrawal latency assessed by the hot-plate test. | 31154140 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Protective Effects of Sinomenine on CFA-Induced Inflammatory Pain in Rats. | 29620048 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Combining behavioral, <i>ex vivo</i> electrophysiological, and morphological approaches in an adult rat model of facial inflammatory pain (complete Freund's adjuvant, CFA), we show that the mechanical allodynia observed 1 h after CFA injection is associated with the following (1) sensitization (using ERK1/2 phosphorylation as a marker) and (2) reduced dendritic arborizations and enhanced spine density in exclusively PKCγ<sup>+</sup> interneurons, but (3) depolarized resting membrane potential (RMP) in all lamina II<sub>i</sub> PKCγ<sup>+</sup>/PKCγ<sup>-</sup> interneurons. | 30355630 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | This effect may involve spinal α1 GlyRs since the expression level of α1 subunits in the spinal cord is positively correlated with CFA-induced inflammatory pain and the GlyRs antagonist strychnine blocks the DH-CBD-induced analgesia. | 29407767 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | ACE was applied to bilateral "Kunlun" (BL60), "Zusanli" (ST36), and "Sanyinjiao" (SP6) acupoints in the rat model of inflammatory pain (complete Freund's adjuvant [CFA] intraplantar injection). | 28682953 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | In the present study, we reported decreased extracellular GABA levels in the VB of rats with CFA-induced chronic inflammatory pain, measured by microdialysis with HPLC analysis. | 28150719 | 2017 | ||||
|
0.070 | GeneticVariation | phenotype | BEFREE | Our results show that ablation of MC in male mice did not result in any change in mechanical and thermal hypersensitivity in the CFA model of inflammatory pain. | 28394852 | 2017 |