Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Dengzhan Shengmai capsules and their active component scutellarin prevent cognitive decline in APP/PS1 mice by accelerating Aβ aggregation and reducing oligomers formation. 31810113 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The APP/PS1 mice began to show cognitive decline at 3 months of age and MCT4 in the hippocampus of 2- and 3-month old APP/PS1 mice was higher than that of C57 mice. 31738978 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE This study aims to estimate whether tan IIA inhibits endoplasmic reticulum (ER) stress-induced apoptosis to prevent cognitive decline in APP/PS1 transgenic mice. 31778727 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Mid infrared light treatment attenuates cognitive decline and alters the gut microbiota community in APP/PS1 mouse model. 31831179 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE These results suggest that phenotypes for onset and rate of cognitive decline vary with PSEN1 and APP genes, suggesting a behavioral heterogeneity in ADAD. 31386938 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice. 30504006 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE In addition, compared to wild-type (WT) mice, while brain perfusion was similar in APP/PS1 mice fed with a chow diet, NAFLD in APP/PS1 mice reveals cerebral hypoperfusion and furthered cognitive decline. 31130652 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE Due to having three copies of the amyloid precursor protein (APP) gene which results in amyloid-beta plaque deposition, the cognitive decline often resembles the decline observed in Alzheimer's disease. 30877730 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Gallic acid disruption of Aβ<sub>1-42</sub> aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. 30447302 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE In this study, we investigated the mechanisms that Aβ-blocked extracellular space (ECS) induces memory disorders in APP/PS1 transgenic mice and addressed whether red light (RL) at 630 nm rescues cognitive decline by reducing Aβ-disturbed flow of interstitial fluid (ISF). 31720368 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression phenotype BEFREE The study suggests that both HIIT and MICT alleviate cognitive decline and down-regulat Aβ level in the hippocampus in APP/PS1 transgenic mice, which may be mediated by improvements in mitochondrial morphology and dynamics. 31445975 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The actions of PGA1 on the production and deposition of Aβ ultimately improved the cognitive decline of the amyloid precursor protein/presenilin1 (APP/PS1) transgenic mice. 30627958 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly <i>via</i> Hippocampal Microglia Modifications. 31024293 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The onset of cognitive decline in APP/PS1 mice generally starts around 6 months of age. 29563870 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). 29331876 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline. 30687079 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 PosttranslationalModification phenotype BEFREE Importantly, we show that inhibition of the Golgi vesicular protein transport causes accumulation of neurotoxic proteins APP, Aβ and phosphorylated Tau, dysproteostasis, unfolded protein response, and apoptosis, which ultimately manifests in progressive cognitive decline, similar to the pathognomonic signatures of familial and sporadic forms of Alzheimer´s disease. 29725009 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in a Finnish population-based cohort. 29807259 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Platelets contain more than 95% of the circulating APP and implicate as a candidate biomarker for cognitive decline. 29775888 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE These results suggest that normal aging may be associated with enhanced neuroinflammation, oxidative stress, and cognitive decline, however distinctions are apparent in the brain of APP/PS1 mice in terms of inflammation and insulin signaling and in certain cognitive domains. 29604345 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Furthermore, enhanced hippocampal neurogenesis in the subgranular zone (SGZ) of the dentate gyrus (DG) and enhanced synaptic plasticity following hAM-MSC treatment could be another important factor in reversing the cognitive decline in APP/PS1 mice. 28397068 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Taken together, these data reveal that male APP/PS1 mice on a C57BL/6J congenic background exhibit a pre-diabetic phenotype prior to the development of AD-like pathology and that this metabolic deficit persists when they exhibit neuropathology and cognitive decline. 28025127 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ<sub>1-42</sub> Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice. 28377712 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline. 27889678 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation phenotype BEFREE Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease. 28108292 2017