Gene: NFE2L2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 AlteredExpression phenotype BEFREE A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway. 31132419 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 AlteredExpression phenotype BEFREE Further studies showed that DOPS could attenuate oxidative stress and reduce neuro-inflammation via up-regulating expressions of Nrf2/HO-1 pathway and inhibiting activation of astrocytes and microglia in ovariectomy- and d-galactose-induced cognitive decline. 30593810 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 Biomarker phenotype BEFREE Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. 29905772 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 Biomarker phenotype BEFREE Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes. 29793180 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 GeneticVariation phenotype BEFREE NFE2L2 rs6721961 T allele was associated with a reduced risk of PD (OR = 0.70, 95% CI = 0.53, 0.94) and slower cognitive decline (β = 0.095; p = 0.0004). 29630901 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.060 Biomarker phenotype BEFREE Our data suggest a clear link between Nrf2 and AD-mediated cognitive decline and further strengthen the connection between Nrf2 and AD. 29036636 2017