Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 GeneticVariation disease BEFREE Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked a TBX5 mutation to atypical Holt-Oram syndrome and paroxysmal AF. 27035640 2016
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease HPO
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease BEFREE We speculate that the gain-of-function mechanism underlies the mild skeletal phenotype and paroxysmal atrial fibrillation and suggest a possible role of TBX5 in the development of (paroxysmal) atrial fibrillation based on a gain-of-function either through a direct stimulation of target genes via TBX5 or indirectly via TBX5 stimulated TBX3. 18451335 2008
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 GeneticVariation disease BEFREE We functionally analyzed a frameshift mutation in the SCN5A gene encoding cardiac Na(+) channels (Nav1.5) found in a proband with repeated episodes of ventricular fibrillation who presented bradycardia and paroxysmal atrial fibrillation. 24363796 2013
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease HPO
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease CTD_human Genome-wide association study of PR interval. 20062060 2010
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease HPO
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease CTD_human Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. 19698954 2010
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease HPO
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 GeneticVariation disease BEFREE Paroxysmal atrial fibrillation (AF) can be caused by gain-of-function mutations in genes, encoding the cardiac potassium channel subunits KCNJ2, KCNE1, and KCNH2 that mediate the repolarizing potassium currents I<sub>k1</sub>, I<sub>ks</sub>, and I<sub>kr</sub>, respectively. 30571183 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease BEFREE Protein levels for the L-type Ca(2+) channel and 5 potassium channels (Kv4.3, Kv1.5, HERG, minK, and Kir3.1) were significantly reduced in both persistent and paroxysmal AF. 11156880 2001
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 7450
Gene Symbol: VWF
VWF
0.310 AlteredExpression disease BEFREE Patients with paroxysmal atrial fibrillation had significantly elevated levels of P -selectin (p = 0.005) and fibrinogen (p = 0.003), but not von Willebrand factor (p =.0.61) compared to controls. 15087601 2003
Entrez Id: 5308
Gene Symbol: PITX2
PITX2
0.310 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 2702
Gene Symbol: GJA5
GJA5
0.310 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. 19597492 2009
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human Meta-analysis identifies six new susceptibility loci for atrial fibrillation. 22544366 2012
Entrez Id: 7450
Gene Symbol: VWF
VWF
0.310 Biomarker disease CTD_human Soluble E-selectin, von Willebrand factor, soluble thrombomodulin, and total body nitrate/nitrite product as indices of endothelial damage/dysfunction in paroxysmal, persistent, and permanent atrial fibrillation. 17890461 2007