Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease HPO
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease HPO
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease HPO
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease HPO
Entrez Id: 3759
Gene Symbol: KCNJ2
KCNJ2
0.100 Biomarker disease HPO
Entrez Id: 8048
Gene Symbol: CSRP3
CSRP3
0.100 Biomarker disease HPO
Entrez Id: 6324
Gene Symbol: SCN1B
SCN1B
0.100 Biomarker disease HPO
Entrez Id: 6327
Gene Symbol: SCN2B
SCN2B
0.100 Biomarker disease HPO
Entrez Id: 51422
Gene Symbol: PRKAG2
PRKAG2
0.100 Biomarker disease HPO
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.100 Biomarker disease HPO
Entrez Id: 3360
Gene Symbol: HTR4
HTR4
0.300 Therapeutic disease CTD_human Do human atrial 5-HT4 receptors mediate arrhythmias? 7886817 1994
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 AlteredExpression disease BEFREE Northern blot analysis revealed enhanced IL-6 mRNA expression in PAF-treated EC. 9187959 1997
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.310 AlteredExpression disease BEFREE This study demonstrates that persistent, but not paroxysmal, AF induces alterations in gene expression of pro-BNP and NPR-A on the atrial level. 10376920 1999
Entrez Id: 10036
Gene Symbol: CHAF1A
CHAF1A
0.010 GeneticVariation disease BEFREE Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. 10807475 2000
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.010 AlteredExpression disease BEFREE The amount of AT(1)-R was reduced to 34.9% during cAF (P<0.01) and to 51.7% during pAF (P<0.05) compared with patients in sinus rhythm. 10851203 2000
Entrez Id: 8850
Gene Symbol: KAT2B
KAT2B
0.010 GeneticVariation disease BEFREE Seventeen patients had chronic persistent AF (> or =6 months; CAF), 8 patients had paroxysmal AF (PAF) and 18 patients had no history of AF. 10807475 2000
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease BEFREE Protein levels for the L-type Ca(2+) channel and 5 potassium channels (Kv4.3, Kv1.5, HERG, minK, and Kir3.1) were significantly reduced in both persistent and paroxysmal AF. 11156880 2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.300 Therapeutic disease CTD_human In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice. 11761419 2001
Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
0.010 Biomarker disease BEFREE ET-A and ET-B receptor protein amounts were significantly reduced in patients with paroxysmal AF (-39% and -47%, respectively) and persistent AF with underlying valve disease (-28% and -30%, respectively) and in persistent AF without valve disease (-20% and -40%, respectively). 11469418 2001
Entrez Id: 55937
Gene Symbol: APOM
APOM
0.010 AlteredExpression disease BEFREE PAF significantly enhanced the apoM mRNA levels and the secretion of apoM in HepG2 cell cultures. 11944906 2002
Entrez Id: 7450
Gene Symbol: VWF
VWF
0.310 AlteredExpression disease BEFREE Patients with paroxysmal atrial fibrillation had significantly elevated levels of P -selectin (p = 0.005) and fibrinogen (p = 0.003), but not von Willebrand factor (p =.0.61) compared to controls. 15087601 2003
Entrez Id: 6403
Gene Symbol: SELP
SELP
0.010 AlteredExpression disease BEFREE Patients with paroxysmal atrial fibrillation had significantly elevated levels of P -selectin (p = 0.005) and fibrinogen (p = 0.003), but not von Willebrand factor (p =.0.61) compared to controls. 15087601 2003
Entrez Id: 1621
Gene Symbol: DBH
DBH
0.010 GeneticVariation disease BEFREE Recent findings of an association between human NE deficiency and variants at the dopamine beta-hydroxylase (DBH) gene [Kim et al., 2002] prompted us to investigate these markers in patients with autonomic disorders; 38 with orthostatic intolerance (OI), 26 with pure autonomic failure (PAF), and 39 with multiple system atrophy (MSA). 12833405 2003
Entrez Id: 2702
Gene Symbol: GJA5
GJA5
0.310 GeneticVariation disease BEFREE This study provides strong evidence linking Cx40 polymorphisms to enhanced atrial vulnerability and increased risk of AF. 15297374 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.300 Biomarker disease CTD_human Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. 15331425 2004