Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4135
Gene Symbol: MAP6
MAP6
0.010 GeneticVariation disease BEFREE Sustained quality-of-life improvement post-cryoballoon ablation in patients with paroxysmal atrial fibrillation: Results from the STOP-AF Post-Approval Study. 31606461 2020
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.010 GeneticVariation disease BEFREE Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. 31393025 2019
Entrez Id: 7702
Gene Symbol: ZNF143
ZNF143
0.010 Biomarker disease BEFREE The STAF risk score for PAF was calculated and compared to the detection rate of PAF for each patient. 30054893 2019
Entrez Id: 4239
Gene Symbol: MFAP4
MFAP4
0.010 AlteredExpression disease BEFREE There were significant differences in MFAP4 levels based on clinical group, with a gradient from control (1.71 ±0.53 ng/ml) to PAF (1.98 ±0.53 ng/ml) to PersAF (2.09 ±0.76 ng/ml) (<i>p</i> < 0.01). 31110528 2019
Entrez Id: 10732
Gene Symbol: TCFL5
TCFL5
0.010 GeneticVariation disease BEFREE Among 1514 patients with AF on warfarin therapy (75±10 years; 42% women; CHA <sub>2</sub> DS <sub>2</sub>- VAS c 3.9±1.7), those most burdened with warfarin therapy were younger and more likely to be women, have paroxysmal AF , and to be treated with antiarrhythmic drugs. 31023126 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.010 AlteredExpression disease BEFREE In addition, p-AF can induce cardiomyocyte fibrosis remodeling and increase MMP-9 expression, and p-AF also increases atrial intracardiac waveform activity by prolonging P<sub>max</sub>, P<sub>min,</sub> PWD, and AERPd and shortening AERP. 31242971 2019
Entrez Id: 375704
Gene Symbol: ENHO
ENHO
0.010 Biomarker disease BEFREE There were decreased serum adropin concentrations in persistent AF group than those in paroxysmal AF group. 30239031 2019
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.010 Biomarker disease BEFREE This study could neither confirm that EAT-V was predictive of recurrence of supraventricular arrhythmias in patients undergoing a hybrid AF ablation, nor that EAT-V was different between patients with paroxysmal AF and persistent and long-standing persistent AF. 30753389 2019
Entrez Id: 3270
Gene Symbol: HRC
HRC
0.010 GeneticVariation disease BEFREE We investigated the association between HRC Ser96Ala and AF recurrence after RFCA in paroxysmal AF (PAF) patients. 30840693 2019
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.010 Biomarker disease BEFREE DRAGON (UMIN-CTR, UMIN000015332) aimed to elucidate the efficacy of pace-capture-guided ablation following contact-force-guided PV isolation ablation in paroxysmal atrial fibrillation (AF) patients. 29161369 2018
Entrez Id: 2047
Gene Symbol: EPHB1
EPHB1
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 6783
Gene Symbol: SULT1E1
SULT1E1
0.010 Biomarker disease BEFREE Patients with atrial septal devices have pre-existing left and right atrial dilation and dysfunction as assessed by 2-D-STE and 3-D-STE that appear sensitive for the stratification of PAF risk in this population. 29609808 2018
Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.010 Biomarker disease BEFREE High circulating adiponectin is independently associated with AF recurrence after catheter ablation for PAF, especially younger than 65 years old. 29016783 2018
Entrez Id: 2004
Gene Symbol: ELK3
ELK3
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 285704
Gene Symbol: RGMB
RGMB
0.010 Biomarker disease BEFREE DRAGON (UMIN-CTR, UMIN000015332) aimed to elucidate the efficacy of pace-capture-guided ablation following contact-force-guided PV isolation ablation in paroxysmal atrial fibrillation (AF) patients. 29161369 2018
Entrez Id: 3751
Gene Symbol: KCND2
KCND2
0.010 GeneticVariation disease BEFREE Through genetic studies, we showed that autosomal dominant early-onset nocturnal paroxysmal AF is caused by p.S447R mutation in KCND2, encoding the pore-forming (α) subunit of the Kv4.2 cardiac potassium channel. 30571183 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.010 AlteredExpression disease BEFREE NLRP3 inflammasome activity was increased in the atrial CMs of patients with paroxysmal AF and chronic AF. 29802206 2018
Entrez Id: 3084
Gene Symbol: NRG1
NRG1
0.010 AlteredExpression disease BEFREE <b>Objective:</b> The present study investigated whether the NRG1/ErbB4 signaling system affects the activity of major atrial ganglionated plexi (GP) in a paroxysmal atrial fibrillation (AF) model by 6-h rapid atrial pacing (RAP). 30246788 2018
Entrez Id: 6898
Gene Symbol: TAT
TAT
0.010 GeneticVariation disease BEFREE PAF can lead to endothelial dysfunction and TAT generation by XO-mediated oxidative stress. 27865966 2017
Entrez Id: 9768
Gene Symbol: PCLAF
PCLAF
0.010 Biomarker disease BEFREE A total of 96 patients (paroxysmal AF [PAF] = 52) who maintained SR during 1 year after AF ablation were enrolled. 27859888 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.010 AlteredExpression disease BEFREE Plasma ACE2 activity levels were increased in AF [control 13.3 (9.5-22.3) pmol/min/mL; PAF 16.9 (9.7-27.3) pmol/min/mL; PersAF 22.8 (13.7-33.4) pmol/min/mL, P = 0.006]. 27738071 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.010 Biomarker disease BEFREE Western blotting of P16 and SA-β-gal staining showed an increased premature senescence in the sinus rhythm, paroxysmal AF and persistent AF groups. 28938531 2017
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.010 Biomarker disease BEFREE Higher levels of sEPCR (203.10 ± 10.33 vs 133.10 ± 7.37 ng/mL; P < .001) and sTM (6.50±0.40 vs 4.48±0.28 ng/mL; P < .001) were measured in PAF. 27313201 2017
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.010 Biomarker disease BEFREE Western blotting of P16 and SA-β-gal staining showed an increased premature senescence in the sinus rhythm, paroxysmal AF and persistent AF groups. 28938531 2017