Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease HPO
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease HPO
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease HPO
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease HPO
Entrez Id: 3759
Gene Symbol: KCNJ2
KCNJ2
0.100 Biomarker disease HPO
Entrez Id: 8048
Gene Symbol: CSRP3
CSRP3
0.100 Biomarker disease HPO
Entrez Id: 6324
Gene Symbol: SCN1B
SCN1B
0.100 Biomarker disease HPO
Entrez Id: 6327
Gene Symbol: SCN2B
SCN2B
0.100 Biomarker disease HPO
Entrez Id: 51422
Gene Symbol: PRKAG2
PRKAG2
0.100 Biomarker disease HPO
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.100 Biomarker disease HPO
Entrez Id: 3084
Gene Symbol: NRG1
NRG1
0.010 AlteredExpression disease BEFREE <b>Objective:</b> The present study investigated whether the NRG1/ErbB4 signaling system affects the activity of major atrial ganglionated plexi (GP) in a paroxysmal atrial fibrillation (AF) model by 6-h rapid atrial pacing (RAP). 30246788 2018
Entrez Id: 55937
Gene Symbol: APOM
APOM
0.010 AlteredExpression disease BEFREE PAF significantly enhanced the apoM mRNA levels and the secretion of apoM in HepG2 cell cultures. 11944906 2002
Entrez Id: 6898
Gene Symbol: TAT
TAT
0.010 GeneticVariation disease BEFREE PAF can lead to endothelial dysfunction and TAT generation by XO-mediated oxidative stress. 27865966 2017
Entrez Id: 2648
Gene Symbol: KAT2A
KAT2A
0.010 Biomarker disease BEFREE PAF-treatment had no effect on other acetylating enzymes (GCN5L2, PCAF) indicating it is not a global activator of histone acetylation. 28157211 2017
Entrez Id: 2047
Gene Symbol: EPHB1
EPHB1
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 2004
Gene Symbol: ELK3
ELK3
0.010 Biomarker disease BEFREE PAF participants were found to have normal abundance of the NE transporter (NET) protein, together with very low levels of tyrosine hydroxylase (TH) (<i>P</i><0.0001) and reduced vesicular monoamine transporter 2 (VMAT2) (<i>P</i><0.05) protein expression compared with control and MSA participants. 29162745 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 GeneticVariation disease BEFREE Paroxysmal atrial fibrillation (AF) can be caused by gain-of-function mutations in genes, encoding the cardiac potassium channel subunits KCNJ2, KCNE1, and KCNH2 that mediate the repolarizing potassium currents I<sub>k1</sub>, I<sub>ks</sub>, and I<sub>kr</sub>, respectively. 30571183 2018
Entrez Id: 7079
Gene Symbol: TIMP4
TIMP4
0.010 Biomarker disease BEFREE TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. 28431065 2017
Entrez Id: 285704
Gene Symbol: RGMB
RGMB
0.010 Biomarker disease BEFREE DRAGON (UMIN-CTR, UMIN000015332) aimed to elucidate the efficacy of pace-capture-guided ablation following contact-force-guided PV isolation ablation in paroxysmal atrial fibrillation (AF) patients. 29161369 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 AlteredExpression disease BEFREE IL-6 levels and MMP-9/TIMP-1 ratio were significantly higher in AF patients than in non-AF controls (P < .001), and in persistent than in paroxysmal AF (P < .001), in line with NT-proBNP and LA diameter. 29324263 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.020 Biomarker disease BEFREE TGF-β1 was negatively correlated with NT-proBNP (r = -0.53, P = .001 in paroxysmal AF and r = -0.71, P < .001 in persistent AF) and LA diameter (r = -0.44, P = .006 in paroxysmal AF and r = -0.51, P = .003 in persistent AF). 29324263 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.010 AlteredExpression disease BEFREE NLRP3 inflammasome activity was increased in the atrial CMs of patients with paroxysmal AF and chronic AF. 29802206 2018
Entrez Id: 6262
Gene Symbol: RYR2
RYR2
0.020 GeneticVariation disease BEFREE A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation: dose-dependent arrhythmia-event suppression by β-blocker therapy. 21652165 2012
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. 19597491 2009