Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 GeneticVariation disease BEFREE Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked a TBX5 mutation to atypical Holt-Oram syndrome and paroxysmal AF. 27035640 2016
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease BEFREE We speculate that the gain-of-function mechanism underlies the mild skeletal phenotype and paroxysmal atrial fibrillation and suggest a possible role of TBX5 in the development of (paroxysmal) atrial fibrillation based on a gain-of-function either through a direct stimulation of target genes via TBX5 or indirectly via TBX5 stimulated TBX3. 18451335 2008
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.420 Biomarker disease HPO
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 GeneticVariation disease BEFREE We functionally analyzed a frameshift mutation in the SCN5A gene encoding cardiac Na(+) channels (Nav1.5) found in a proband with repeated episodes of ventricular fibrillation who presented bradycardia and paroxysmal atrial fibrillation. 24363796 2013
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease CTD_human Genome-wide association study of PR interval. 20062060 2010
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.410 Biomarker disease HPO
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease CTD_human Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. 19698954 2010
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.400 Biomarker disease HPO
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
0.400 Biomarker disease HPO
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 GeneticVariation disease BEFREE Paroxysmal atrial fibrillation (AF) can be caused by gain-of-function mutations in genes, encoding the cardiac potassium channel subunits KCNJ2, KCNE1, and KCNH2 that mediate the repolarizing potassium currents I<sub>k1</sub>, I<sub>ks</sub>, and I<sub>kr</sub>, respectively. 30571183 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.320 Biomarker disease BEFREE Protein levels for the L-type Ca(2+) channel and 5 potassium channels (Kv4.3, Kv1.5, HERG, minK, and Kir3.1) were significantly reduced in both persistent and paroxysmal AF. 11156880 2001
Entrez Id: 5308
Gene Symbol: PITX2
PITX2
0.310 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 2702
Gene Symbol: GJA5
GJA5
0.310 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 GeneticVariation disease BEFREE We genotyped ZFHX3 SNP rs2106261 and compared the minor (T) allele frequency between 362 paroxysmal AF (PAF) patients underwent pulmonary vein isolation (PVI) and 627 non-AF controls. 30180182 2018
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.310 Biomarker disease CTD_human Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
Entrez Id: 2702
Gene Symbol: GJA5
GJA5
0.310 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
Entrez Id: 5308
Gene Symbol: PITX2
PITX2
0.310 GeneticVariation disease BEFREE Since the proband developed paroxysmal AF at a young age, we screened 17 polymorphisms associated with AF risk in this family and showed that the proband carries at-risk polymorphisms upstream of PITX2, a gene widely associated with AF development. 24582607 2014