Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 AlteredExpression disease BEFREE While retaining normal systemic iron levels, this model developed PAH and right heart failure as a consequence of intracellular iron deficiency and increased expression of the vasoconstrictor endothelin-1 (ET-1) within PASMCs.PAH was prevented and reversed by i.v. iron and by the ET receptor antagonist BQ-123. 31152133 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.320 Biomarker disease BEFREE Based on current evidence, we suggest the potential utility of ST2, sST2, Gal-3, CRP, hs-cTn, and NT-proBNP in predicting and detecting RVF in cardiac surgery patients, as they encompass the multifaceted nature of perioperative RVF and warrant further investigation to establish their clinical utility. 31027170 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.320 GeneticVariation disease BEFREE Postop RVF was associated with a higher preop WBC (11.3 + 5.7 vs 8.7 + 3.1) and C-reactive protein (CRP, 5.6 + 4.4 vs 3.3 + 4.7) levels. 31023326 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.320 Biomarker disease BEFREE PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. 29695452 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease BEFREE However, positive staining for ET-1 was also seen in rats' hearts that suffered from arrhythmias after electric shock and in the myocardium of the right ventricle in human control cases in which a right heart failure has to be discussed. 29151120 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.320 Biomarker disease BEFREE PPARγ agonist prevented PAH-induced RVF by preserving RV index and preventing RVH. 29151490 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.320 Biomarker disease CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611 2016
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). 16762801 2006
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.320 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes. 11707688 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure. 11136700 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. 9861300 1998
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology. 7967349 1994
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Plasma endothelin-1 and doxorubicin cardiotoxicity. 7969316 1994
Entrez Id: 183
Gene Symbol: AGT
AGT
0.310 Biomarker disease BEFREE Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure. 31307846 2019
Entrez Id: 7450
Gene Symbol: VWF
VWF
0.310 AlteredExpression disease BEFREE This study aimed to compare von Willebrand factor (vWF) levels, ristocetin cofactor levels, platelet counts, aortic valve movements, and right heart failure (RHF) as risk factors of gastrointestinal (GI) bleeding in patients with continuous flow left ventricular assist device (cf-LVAD). 28957820 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.310 AlteredExpression disease BEFREE Our findings indicate that the myocardium of rats with monocrotaline-induced right ventricular failure is deficient with activation of local RAS and therefore expresses blunted SFR, very similar to the depression of SFR observed in normal myocardium under inhibition of AT1 receptors. 29593122 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.310 Biomarker disease CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.310 Biomarker disease BEFREE Furthermore, right ventricle-targeted therapies, aimed at mitigating the effects of functional right ventricular failure, include β-adrenoceptor (β-AR) blockers, angiotensin-converting enzyme (ACE) inhibitors, antioxidants, modulators of metabolism, and 5-hydroxytryptamine-2B (5-HT2B) receptor antagonists. 26583148 2015
Entrez Id: 3357
Gene Symbol: HTR2B
HTR2B
0.310 Biomarker disease BEFREE Furthermore, right ventricle-targeted therapies, aimed at mitigating the effects of functional right ventricular failure, include β-adrenoceptor (β-AR) blockers, angiotensin-converting enzyme (ACE) inhibitors, antioxidants, modulators of metabolism, and 5-hydroxytryptamine-2B (5-HT2B) receptor antagonists. 26583148 2015
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2
0.310 Biomarker disease BEFREE Current management of patients with pulmonary arterial hypertension and symptoms of right heart failure includes use of mineralocorticoid receptor antagonists for their diuretic and natriuretic effects. 23547564 2013
Entrez Id: 7450
Gene Symbol: VWF
VWF
0.310 Biomarker disease CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2
0.310 Biomarker disease CTD_human Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. 21321305 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.310 Biomarker disease CTD_human Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. 20811386 2010