| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | In addition, oridonin suppressed GBC cell growth and downregulated the expression levels of HIF-1α and MMP-9 in a GBC-SD cell xenograft model. | 31517732 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our results indicate that IL-37 plays an antitumor role during the progression of gallbladder carcinoma.IL-37 could inhibit HIF1α induced EMT. | 30556856 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Real‑time quantitative polymerase chain reaction analysis and immunohistochemistry experiments revealed that HIF‑1α was significantly upregulated in GBC tissues. | 30272364 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | We revealed that miR-138 is a suppressor of GBC cell metastasis and EMT progression, and a similar phenomenon was observed in HIF-1α knockdown NOZ cells. | 28077595 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Altogether, our studies identified a novel regulator, miR-143-5p, implicated in GBC prognosis through targeting HIF-1α/EMT related signaling pathway, which could serve as a biomarker and therapeutic target for GBC. | 28803245 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | In this study, we have investigated the role of HIF-1α in the pathobilogy of GBC and effect of hispidulin on the molecular events controlled by this transcription factor. | 25499970 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1α (HIF-1α) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells. | 25046749 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Moreover, VM and HIF-1α were independent factors for the overall survival of GBC patients and correlated with decreased survival. | 22470047 | 2012 |