| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Recent reports have determined TNF-α associated lymphatic metastasis in GBC, while its resistance to TNF-α-killing remains largely unexplored. | 30902881 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The RIP1 protein levels in the GBC-SD and NOZ cells upon stimulation with increasing concentrations of TNF-α as indicated was examined using Western blot. | 29844685 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | After treatment with various concentrations of TNF-α, CCR7 expression in GBC cell lines was measured by Western blotting. | 27009073 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our data provide evidence that autocrine TNF-α plays a role as a tumor promoter gene in gallbladder cancer cells, possibly by promoting proliferation and invasion through autocrine mechanisms. | 24676340 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Taken together, TNF-α can upregulate the expression of VEGF-C and promote the lymphangiogenesis of GBC via NF-κB combining with the promoter of VEGF-C. | 25154789 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These results suggest that TNFA -308 (G/A) polymorphism may influence the susceptibility of female gender gallbladder cancer in absence of gallstones while IL6 -174 G/C polymorphism does not seem to be playing significant role in the susceptibility to gallbladder cancer. | 18260730 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | Furthermore, the combined treatment with the c-FLIP siRNA and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) significantly induced apoptosis in gallbladder carcinoma cells, as judged by the increases in pyknosis, caspase-3/7 activities, and Annexin V-propidium iodide labeling, a marker for chromatin condensation. | 19282655 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The expression of TNFmRNA, TNF and TNFR was detected by in situ hybridization and immunohistochemistry on the surgical specimens of hyperplasia, dysplasia and carcinoma of the gallbladder. | 15313687 | 2004 |