The role of SorCS2 in the acute and adapted response to alcohol was therefore investigated by comparing SorCS2 knockout (<i>Sorcs2<sup>-/-</sup></i> ) mice to wild type (WT) mice in three paradigms modeling alcohol sensitivity and consumption; alcohol-induced conditioned place preference, two-bottle choice test as well as the behavioral response to alcohol withdrawal.
The top association signal for AW severity was in sortilin family neurotrophin receptor gene SORCS2 on chromosome 4 (European American meta-analysis n = 1,478, p = 4.3 × 10<sup>-9</sup> ).