Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.300 Biomarker disease PSYGENET Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. 17471289 2008
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.050 GeneticVariation disease BEFREE The ALDH2 polymorphisms might have different effects on the neuropsychological performance of BP-II patients with and without comorbid AD. 29425204 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.050 Biomarker disease BEFREE Memory Impairment and Plasma BDNF Correlates of the <i>BDNF Val66Met</i> Polymorphism in Patients With Bipolar II Disorder. 30542371 2018
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.050 Biomarker disease BEFREE In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP-II+AD group. 26033520 2015
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.050 Biomarker disease BEFREE Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder. 23835015 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.050 GeneticVariation disease BEFREE We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II. 24103632 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.050 GeneticVariation disease BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.050 GeneticVariation disease BEFREE We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. 22877924 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.050 Biomarker disease BEFREE The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder. 22514151 2012
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.050 Biomarker disease BEFREE Our findings provide initial evidence that the ALDH2 and 5-HT2A genes interact in bipolar-I but not in bipolar-II disorder. 22564712 2012
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.050 Biomarker disease BEFREE However, there was no association between the ALDH2 or DRD2/ANKK1 gene with neither bipolar I nor bipolar II disorder. 20577142 2010
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.030 Biomarker disease BEFREE The dopamine receptor D3 (DRD3) gene, one of the candidate genes for BDII, is also involved in the dopaminergic system. 27310943 2016
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.030 GeneticVariation disease BEFREE Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. 25744938 2015
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.030 GeneticVariation disease BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378 2013
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.030 GeneticVariation disease BEFREE We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. 22877924 2012
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.030 Biomarker disease BEFREE The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder. 20698735 2011
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.030 Biomarker disease BEFREE The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder. 20698735 2011
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.020 Biomarker disease BEFREE The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder. 22514151 2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.020 Biomarker disease BEFREE However, there was no association between the ALDH2 or DRD2/ANKK1 gene with neither bipolar I nor bipolar II disorder. 20577142 2010
Entrez Id: 23263
Gene Symbol: MCF2L
MCF2L
0.010 Biomarker disease BEFREE Long-term outcome data were collected for 28 patients (20 with major depressive disorder and seven with bipolar II disorder; one patient in the major depression subgroup was later reclassified as having bipolar II disorder) receiving SCC DBS for 4-8 years. 31581800 2019
Entrez Id: 4036
Gene Symbol: LRP2
LRP2
0.010 Biomarker disease BEFREE Long-term outcome data were collected for 28 patients (20 with major depressive disorder and seven with bipolar II disorder; one patient in the major depression subgroup was later reclassified as having bipolar II disorder) receiving SCC DBS for 4-8 years. 31581800 2019
Entrez Id: 2784
Gene Symbol: GNB3
GNB3
0.010 GeneticVariation disease BEFREE At baseline, the GNB3 C825T polymorphisms were associated with the triglyceride level (P=0.032) in BP-II patients. 26856249 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 AlteredExpression disease BEFREE Objectives We aimed to examine whether the C-reactive protein (CRP) level could be used to differentiate between major depressive disorder (MDD) and bipolar II disorder (BD II). 26895280 2017
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.010 Biomarker disease BEFREE In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP-II+AD group. 26033520 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.010 Biomarker disease BEFREE Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II. 25744938 2015