Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.010 GeneticVariation disease BEFREE Male breast cancer in Cowden syndrome patients with germline PTEN mutations. 11238682 2001
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE Male breast cancer was associated with BRCA2 mutations. 11802208 2002
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE Male breast cancer has been linked extensively to mutations of BRCA2 and, to a lesser extent, BRCA1. 17592676 2007
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE Male breast cancer is poorly understood with a large proportion arising in the familial context particularly with the BRCA2 germline mutation. 24457463 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.100 AlteredExpression disease BEFREE Male breast cancer is a hormone-driven disease that often expresses the estrogen receptor, and antiestrogen therapy represents the mainstay of treatment. 26276719 2015
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 GeneticVariation disease BEFREE Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. 26857456 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. 26857456 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 GeneticVariation disease BEFREE Male breast cancer (MBC) is a rare cancer entity, with mutations in BRCA1 and BRCA2 genes accounting for ~ 10% of patients. 29335925 2018
Entrez Id: 367
Gene Symbol: AR
AR 		0.400 AlteredExpression disease BEFREE Androgen receptor expression in male breast carcinoma: lack of clinicopathological association. 10070897 1999
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 GeneticVariation disease BEFREE BRCA1/2 mutation analysis in male breast cancer families from North West England. 17636422 2008
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 Biomarker disease BEFREE BRCA2-associated MBCs presented with high tumor grade (p=0.001), PR-(p=0.026) and HER2+ (p=0.001) status. 22527108 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.100 PosttranslationalModification disease BEFREE ESR1 and GSTP1 promoter hypermethylation seem to be involved in development and/or progression of high-grade male breast cancer. 22765268 2012
Entrez Id: 6817
Gene Symbol: SULT1A1
SULT1A1 		0.020 GeneticVariation disease BEFREE SULT1A1 gene deletion was observed in 10 of the 72 MBCs (13.9%). 23711090 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.030 GeneticVariation disease BEFREE PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer. 23971979 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE BRCA2 mutation-carriers were associated with families with at least one MBC and one BC in female (type II; p = 0.05). 26026974 2015
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.100 GeneticVariation disease BEFREE BRCA1 gene mutation seems to be related to male breast cancer, but its role is not clearly defined. 26085381 2015
Entrez Id: 367
Gene Symbol: AR
AR 		0.400 Biomarker disease BEFREE Androgen receptor and antiandrogen therapy in male breast cancer. 26276719 2015
Entrez Id: 9087
Gene Symbol: TMSB4Y
TMSB4Y 		0.010 Biomarker disease BEFREE TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. 26702755 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.100 Biomarker disease BEFREE Human epidermal growth factor receptor 2 (HER2) was positive in 26.8 % of cases; 7.0 % of MBCs were triple negative. 27377827 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.070 GeneticVariation disease BEFREE TP53 (3%) somatic mutations were significantly less frequent in MBC compared to smFBC whereas somatic mutations in genes regulating chromatin function and homologous recombination deficiency-related signatures were more prevalent. 31340200 2019
Entrez Id: 4082
Gene Symbol: MARCKS
MARCKS 		0.010 AlteredExpression disease BEFREE MARCKS was overexpressed in epithelial tumor cells in 66% of the MBC samples versus 26% of normal samples (p= 1.40 × 10-7). 31771045 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE BRCA2 germline mutations in male breast cancer cases and breast cancer families. 8673091 1996
Entrez Id: 367
Gene Symbol: AR
AR 		0.400 GeneticVariation disease BEFREE Arg607-Gln and Arg608-Lys point mutations in the DNA-binding domain of the AR gene have been associated with male breast cancer in partial androgen insensitivity syndrome. 10221692 1999
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE A BRCA2 gene mutation was identified in four MBC patients. 18439106 2008
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.100 GeneticVariation disease BEFREE A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer? 15519522 2004