Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9172
Gene Symbol: MYOM2
MYOM2
0.030 Biomarker disease BEFREE We conclude that the group A streptococcal hyaluronic acid capsule and M protein, but not the cysteine protease, are critical for the development of tissue necrosis, secondary bacteremia, and lethal infection in a murine model of human necrotizing fasciitis. 9691092 1998
Entrez Id: 5866
Gene Symbol: RAB3IL1
RAB3IL1
0.010 AlteredExpression disease BEFREE Antibody levels against the cell wall-attached GAS antigens SclA, SclB, and GRAB were significantly lower in patients with severe invasive disease (streptococcal toxic shock syndrome [STSS] and/or necrotizing fasciitis [NF]; n=35), compared with levels in patients with nonsevere GAS bacteremia (n=35). 14976595 2004
Entrez Id: 10479
Gene Symbol: SLC9A6
SLC9A6
0.010 Biomarker disease BEFREE Monomicrobial MRSA NF accounted for three cases, with all of the patients reporting a distinct "spider bite" lesion 2-3 days prior to admission. 18399783 2008
Entrez Id: 8434
Gene Symbol: RECK
RECK
0.010 GeneticVariation disease BEFREE Necrotizing fasciitis was often associated with ST-15/emm-3. 18417661 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.010 AlteredExpression disease BEFREE The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upregulated in vivo in the M1T1 GAS strains associated with life-threatening systemic disease including necrotizing fasciitis. 18692776 2008
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.020 Biomarker disease BEFREE These findings suggest that human CD46 enhanced the progression of NF in the feet and the exponential growth of bacteria in deep tissues, leading to death. 19737905 2009
Entrez Id: 3120
Gene Symbol: HLA-DQB2
HLA-DQB2
0.010 GeneticVariation disease BEFREE Both patients shared the HLA DQB1*0301 allele, which has been associated with susceptibility to GAS necrotizing fasciitis. 19828348 2010
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.010 GeneticVariation disease BEFREE Both patients shared the HLA DQB1*0301 allele, which has been associated with susceptibility to GAS necrotizing fasciitis. 19828348 2010
Entrez Id: 2775
Gene Symbol: GNAO1
GNAO1
0.010 GeneticVariation disease BEFREE Both patients shared the HLA DQB1*0301 allele, which has been associated with susceptibility to GAS necrotizing fasciitis. 19828348 2010
Entrez Id: 9172
Gene Symbol: MYOM2
MYOM2
0.030 GeneticVariation disease BEFREE We present two cases of invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis, one that showed rapidly developing necrotizing fasciitis in a previously healthy man and one that showed severe cellulitis and septic shock even though the bacterium possessed a mutated emm gene, predicted to encode a truncated M protein. 20147644 2010
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.030 Biomarker disease BEFREE Our findings indicate a considerable burden of both iGAS and iGCS/GGS disease and a high frequency of necrotizing fasciitis caused by GAS in our community. 20456456 2011
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.030 Biomarker disease BEFREE Our findings indicate a considerable burden of both iGAS and iGCS/GGS disease and a high frequency of necrotizing fasciitis caused by GAS in our community. 20456456 2011
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.030 Biomarker disease BEFREE Our findings indicate a considerable burden of both iGAS and iGCS/GGS disease and a high frequency of necrotizing fasciitis caused by GAS in our community. 20456456 2011
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.030 Biomarker disease BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.030 Biomarker disease BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.030 Biomarker disease BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 22848
Gene Symbol: AAK1
AAK1
0.010 Biomarker disease BEFREE We present here the first genome sequence of A. aquariorum strain AAk1, which was isolated as the sole pathogen from the blood of a patient with septicemia and necrotizing fasciitis. 22815437 2012
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.020 Biomarker disease BEFREE Human CD46-expressing transgenic (Tg) mice developed necrotizing fasciitis associated with osteoclast-mediated progressive and severe bone destruction in the hind paws 3 days after subcutaneous infection with 5 × 10(5) colony-forming units of GAS472. 26894505 2016
Entrez Id: 9172
Gene Symbol: MYOM2
MYOM2
0.030 Biomarker disease BEFREE M protein is the most abundant GAS surface protein, and M1 serotype GAS strains are associated with invasive infections, including necrotizing fasciitis and toxic shock syndrome. 28784982 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 AlteredExpression disease BEFREE In this case report we evaluate the diagnostic process of a patient with NF without aberrant infection parameters; both normal levels of CRP and white blood cell count were seen. 28978607 2017
Entrez Id: 722
Gene Symbol: C4BPA
C4BPA
0.010 Biomarker disease BEFREE Electron microscopy analysis of human tissue samples with necrotizing fasciitis confirmed increased C4BP binding to <i>S. pyogenes</i> when IgG was present. 29626087 2018
Entrez Id: 725
Gene Symbol: C4BPB
C4BPB
0.010 Biomarker disease BEFREE Electron microscopy analysis of human tissue samples with necrotizing fasciitis confirmed increased C4BP binding to <i>S. pyogenes</i> when IgG was present. 29626087 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.010 GeneticVariation disease BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 129831
Gene Symbol: RBM45
RBM45
0.010 GeneticVariation disease BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 2615
Gene Symbol: LRRC32
LRRC32
0.010 Biomarker disease BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018