Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation group BEFREE Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1. 28762371 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation group BEFREE We first established that GISTs carrying EGFR mutation are relatively benign tumours. 28485054 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE However, whereas HER2 has been excluded as a therapeutic biomarker, both EGFR and IGF1R are expressed by some wild-type GISTs and are therefore potential therapeutic targets. 25659413 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE Targeting c-Kit plus HER1 or AXL/c-Met abrogates IM resistance in GIST. 25557174 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation group BEFREE The final section will discuss the 4 most mature examples in the GI tract: (1) HER2 testing to select patients with advanced gastroesophageal adenocarcinoma for anti-HER2 therapy, (2) KIT and PDGFRA mutation analysis to direct tyrosine kinase inhibitor therapy in gastrointestinal stromal tumor, (3) DNA mismatch repair function testing to determine the applicability of adjuvant chemotherapy in patients with stage II colorectal cancer (CRC), and (4) KRAS mutation analysis and related testing to determine the appropriateness of anti-EGFR monoclonal antibody therapy in patients with metastatic CRC. 24342289 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation group BEFREE Good examples are (1) trastuzumab, hMAB against HER2 in breast cancers with HER2 over-expression and amplification, (2) imatinib, TKI, for gastrointestinal stromal tumors (GISTs) with c-kit mutation, (3) gefitinib, TKI, for lung adenocarcinoma with EGFR mutation. 19891708 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE Considered together, the results suggest that ADAM17 may contribute to the progression and growth of GIST through shedding of EGFR ligands and consequent EGFR stimulation. 19298600 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression group LHGDN Expression of EGFR in some gastric GISTs might be of clinical significance with the recent emergence of EGFR-targeted therapies. 18528288 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE Selective KIT, PDGFRalpha and epidermal growth factor receptor (EGFR) tyrosine kinase inhibition evolved as powerful targeted therapy for gastrointestinal stromal tumours and non-small-cell lung cancer. 18478259 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression group BEFREE The expression profile of EGFR in gastrointestinal stromal tumors (GISTs) is derived from a limited number of small series samples and case reports. 18528288 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE On the basis of the involvement of these RTKs in the pathogenesis of these disorders, Ménétrier disease patients have been effectively treated with a blocking monoclonal antibody specific for EGFR and GIST patients with KIT and PDGFRA tyrosine kinase inhibitors. 17200708 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression group LHGDN Variable epidermal growth factor receptor protein immunohistochemical overexpression was detected in 96% of gastrointestinal stromal tumor cases, but none of the 75 cases with represented tumor tissue cores and countable fluorescence signals exhibited epidermal growth factor receptor gene amplification by fluorescence in situ hybridization. 17643098 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression group BEFREE Variable epidermal growth factor receptor protein immunohistochemical overexpression was detected in 96% of gastrointestinal stromal tumor cases, but none of the 75 cases with represented tumor tissue cores and countable fluorescence signals exhibited epidermal growth factor receptor gene amplification by fluorescence in situ hybridization. 17643098 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker group BEFREE In addition to paralleling what is already known about c-kit mutations that drive the proliferation of gastrointestinal stromal tumors and their response to imatinib, and providing the possibility of prospectively selecting patients with NSCLC who have a high probability of responding to EGFR TK inhibitors, these reports will likely have much broader implications with regard to the optimal and most expeditious means to develop rationally designed, target-based therapeutic agents--first establishing proof of principle in patients whose malignancies are dependent or driven by aberrations of the therapeutic's target. 15638956 2004