Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE Here, kinetics and thermodynamics of cyanide, thiocyanate and imidazole binding to ferric human Hb (Hb(III)), Hb(III) dimers complexed with the human Hp phenotypes 1-1 and 2-2 (Hp1-1:Hb(III) and Hp2-2:Hb(III), respectively), and α(III) and β(III) chains are reported and analyzed in parallel with fluoride and azide binding properties (at pH 7.0 and 20.0 °C). 31733428 2020
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE In women with T1DM, although Hp phenotype did not predict PE risk, lipoprotein-related risks for PE were limited to those with the Hp 2-2 phenotype. 31219590 2019
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE Here, kinetics and thermodynamics of fluoride and azide binding to ferric human Hb (Hb(III)) complexed with the human Hp phenotypes 1-1 and 2-2 (Hp1-1:Hb(III) and Hp2-2:Hb(III), respectively) are reported (pH 7.0 and 20.0 °C). 30706146 2019
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE The study included 94 patients.The distribution of Hp phenotype was Hp 1-1, 12 (13%); Hp 2-1, 46 (49%); and Hp 2-2, 36 (38%). 25527876 2015
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 Biomarker disease BEFREE There were no significant differences in malaria parasite densities among Hp phenotypes but children with Hp 2-2 had lower number of clinical malaria episodes (P=0.045). 23416122 2013
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 Biomarker disease BEFREE In summary, we could not establish a correlation between Hp phenotype and oocyte number or IVF outcomes though the Hp2-2 phenotype may be protective against mechanical factor infertility. 23651415 2013
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE Additionally, correlations according to Hp phenotypes revealed strong association between ceruloplasmin ferroxidase activity and serum ferritin in patients with Hp 2-2 phenotype and not in the others (r=0.331, p<0.05). 21315066 2011
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
0.080 GeneticVariation disease BEFREE We propose that previous conflicting results between Hp phenotypes/genotypes and malaria susceptibility may be explained by differing prevalence of the A-61C SNP in the populations studied, which we found to be highly associated with the Hp2 allele. 17426810 2007