For EBV-negative GC, patients with HP infection had fewer <i>PI3K/AKT</i> pathway mutations and a better 5-year overall survival and disease-free survival than those without HP infection.
<i>In vitro</i> cell experiments revealed that the PI3K activity was enhanced and the PI3K/Akt pathway was significantly activated after HP infection in tumor cells, thus promoting the proliferation of tumor cells (p<0.05) in a time-dependent manner.