Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE 5-HIAAA = 5-hydroxyindoleacetic acid; 5-HTP = 5-hydroxytryptophan; CGA = chromogranin A; ETM = endocrine tumor marker; MTC = medullary thyroid carcinoma; UHLETM = unexpectedly high level of endocrine tumor marker. 30106635 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 GeneticVariation disease BEFREE Genetic testing for the RET gene variants was performed with standard methods in 585 people aged 1-85, including 448 patients with medullary thyroid carcinoma and 131 of their first- and second-degree relatives, as well as six patients suspected of MTC/MEN2. 28647780 2017
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE Although in silico analysis may be helpful in quantitating changes in protein structure that occur in patients who have novel RET mutations (single or multiple), additional factors must account for the highly variable aggressiveness of the disease (C-cell hyperplasia/medullary thyroid carcinoma [MTC]) noted in our kindred. 26876062 2016
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 GeneticVariation disease BEFREE A subset of MTC cases is hereditary and due to germline mutations in the RET tyrosine kinase receptor gene. 25972318 2015
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 GeneticVariation disease BEFREE Inhibitors of RET, a tyrosine kinase receptor encoded by a gene that is frequently mutated in medullary thyroid cancer, have emerged as promising novel therapies for the disease. 23828865 2013
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE Calcium-sensing receptor (CaSR) is expressed by parathyroid cells and thyroid C-cells (from which medullary thyroid carcinoma [MTC] is derived). 24238055 2013
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 GeneticVariation disease BEFREE Hereditary medullary thyroid carcinoma (hereditary MTC) is a rare malignancy, accounting for 25-30% of all MTC. 22183190 2012
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 AlteredExpression disease BEFREE Activating mutations of RET, a gene encoding two isoforms of a tyrosine kinase receptor physiologically expressed in several neural crest-derived cell lineages, are associated with the inherited forms of medullary thyroid carcinoma (MTC). 21690267 2011
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE The identification of activating mutations of the RET tyrosine kinase receptor in both hereditary and sporadic MTC makes this malignant disease an excellent model for examination of the effect of a group of small organic molecule TKIs for treatment of metastatic MTC. 19546050 2010
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 GeneticVariation disease BEFREE Using a proteomic-multiplexed analysis of the phosphotyrosine signaling together with antibody-based validation techniques, we identified several candidate molecules for RET (rearranged during transfection) tyrosine kinase receptor carrying mutations responsible for the multiple endocrine neoplasia type 2A and 2B (MEN2A and MEN2B) syndromes in two human medullary thyroid carcinoma (MTC) cell lines, TT and MZ-CRC-1, which express the RET-MEN2A and RET-MEN2B oncoproteins, respectively. 18756447 2009
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE The RET tyrosine kinase receptor was discovered two decades ago as a transforming gene and was subsequently implicated in the formation of papillary and medullary thyroid carcinoma. 18502331 2008
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE Activating mutations in the RET gene, which encodes a tyrosine kinase receptor, often cause medullary thyroid carcinoma (MTC). 16782438 2006
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE In addition, this and other mutations can help us to understand some features about domains that play an important role in the normal function of this tyrosine kinase receptor and involved in MTC. 11883863 2002
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE Because of similarities in involvement of the two tyrosine kinases RET (rearranged during transfection) and NTRK1 in the pathogenesis of PTC, the obvious parallels between RET and NTRK1 and between PTC and medullary thyroid carcinoma (MTC), NTRK1 seemed to be an excellent candidate gene to play a role in the genesis of MTC. 10443680 1999
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease BEFREE The clinical subtypes of MEN 2 (MEN 2A, MEN 2B and familial MTC) all have medullary thyroid carcinoma, but vary in the involvement of pheochromocytoma, parathyroid adenoma/hyperplasia and developmental abnormalities. 9294615 1997
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.200 Biomarker disease HPO