Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 Biomarker disease BEFREE Overall, our results unveil plasma miR-375 as a promising prognostic marker for advanced MTC patients, to be validated in larger cohorts. 29298817 2018
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 Biomarker disease BEFREE Our results suggest miR-375 plays a central role in MTC progression and, therefore, we seek following the idea that miR-375 pathway may be an effective target in novel MTC therapeutic strategies. 28861609 2017
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 Biomarker disease BEFREE Furthermore, we conducted in silico analysis including gene ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways annotations and Protein-Protein Interactions (PPI) analysis to provide an overview of the function of miR-375 in MTC. 29033189 2017
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 AlteredExpression disease BEFREE We confirmed these results through SEC23A direct silencing in combination with vandetanib, highlighting the importance of SEC23A in the miR-375-associated increased sensitivity to vandetanib.Since the combination of increased expression of miR-375 and decreased expression of SEC23A point to sensitivity to vandetanib, we question if the expression levels of miR-375 and SEC23A should be evaluated as an indicator of eligibility for treatment of MTC patients with vandetanib. 27036030 2016
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 Biomarker disease BEFREE Total RNA was extracted and quantitave polymerase chain reaction (qPCR) analysis performed on the primary tumour and a corresponding lymph node metastasis for expression of miRNAs of proven significance in MTC (miR-9*, miR-183 and miR-375). 23072640 2014
Entrez Id: 494324
Gene Symbol: MIR375
MIR375
0.060 AlteredExpression disease BEFREE Thus, differential expression of miR-375, miR-10a and miR-455 may be important for tumor development and/or reflect C-cell lineage of medullary thyroid carcinoma. 23685355 2013