|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TERT promoter have been detected in the more aggressive papillary thyroid cancers (PTCs).
|
30661164 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutations (any type) were detected in 13.5% (77/568) of PTC cases with known BRAF status.
|
31305897 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Coexisting BRAF<sup>V600E</sup> and TERT promoter mutations were detected in a subgroup of aggressive PTCs (12%).
|
30501571 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mechanism of the synergistic effect between BRAFV600E and TERT promoter mutations on cancer invasiveness and progression in PTC may be explained by increased TERT expression, which may result from the BRAF-induced upregulation of several ETS transcription factors.
|
30999281 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed mutations of BRAF (V600E) and TERT promoter (C228T, C250T) in tumor DNA from 141 patients (75 with classical variant PTC, CVPTC; 66 with follicular variant PTC, FVPTC) recruited through a multi-center study.
|
31454788 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified duplication of Chr1q, duplication of Chr5p harboring the TERT genomic locus and mutations of TERT promoter as distinctive features of DM PTCs.
|
29416733 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this work, a DNA microarray-based resonance light scattering (RLS) assay has been developed for multiplexed detection of papillary thyroid carcinoma (PTC) related mutation points including BRAF<sup>V600E</sup> (t1m), NRAS codon 61 (t2m), TERT promoter g.1295228 (t31m) and TERT promoter g.1295250 (t32m) with high sensitivity and selectivity by the attachment of polyvalent ssDNA modified 13 nm gold nanoparticles (ssDNAs@GNPs) followed by silver deposition for signal enhancement.
|
29362729 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common C228T TERT promoter mutation was identified in 2 PTC cases co-existing with the BRAF mutation.
|
30361901 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the incidence of TERT promoter mutations and TERT protein expression and their association with clinicopathological outcomes in a large cohort of PTC samples using direct sequencing technology and immunohistochemistry.
|
29266240 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We showed that the ATC/DM-PTC group had an overall mutational load higher than ctrl-PTCs and that ATCs and DM-PTCs are characterized by a different genetic background, with the exception of mutations in the TERT promoter that were overrepresented in both ATCs (61.1%) and DM-PTCs (48.2%) vs non-aggressive ctrl-PTCs (7.6%).
|
30400028 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Exclusion of mutations in TP53 and the TERT promoter could be considered as an adjunct tool when assessing papillary thyroid cancer with focal pleomorphism.
|
29976183 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutations were likely to occur in a sub-clonal manner in our PTC cohort.
|
29144541 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we used the KTC1 cell line as a model for human advanced papillary thyroid cancer (PTC) because the cells harbor the heterozygous BRAF (V600E) mutation together with the C250T TERT promoter mutation.
|
30265861 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TERT promoter mutations were associated with proliferative and metabolic alterations in PTC.
|
30102829 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combination of BRAF and TERT promoter mutations could classify PTCs into four distinct risk groups with decreasing aggressiveness as follows: coexisting BRAF and TERT > TERT alone=BRAF alone > no mutations.
|
28666074 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation in this genetic interplay remains to be established.
|
27875244 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutation (C228T) was identified in 2 ATC and one HVPTC patient.
|
28423545 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ultrasonographic prediction of highly aggressive telomerase reverse transcriptase (TERT) promoter-mutated papillary thyroid cancer.
|
28616852 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling index (LI) as a prognostic marker in PTC patients.
|
28150740 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aims to evaluate the frequencies of BRAF and TERT promoter mutations and to examine their significance in non-radiation-associated pediatric PTCs in Japan.
|
28176151 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papillary Thyroid Carcinoma.
|
27688081 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, molecular testing of BRAF<sup>V600E</sup> and TERT promoter mutations together is useful in assessing risk stratification of PTC.
|
28181854 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutations occur at a higher rate than that seen in PTC in general and may help explain the aggressive behavior of these histologically deceptive primary carcinomas.
|
28049366 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of molecular markers to predict distant metastasis in papillary thyroid carcinoma: Promising value of TERT promoter mutations and insignificant role of BRAF mutations-a meta-analysis.
|
29037127 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF V600E and TERT promoter mutation patterns and associated patient deaths caused by PTC.
|
27581851 |
2017 |