Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 AlteredExpression disease BEFREE Seventeen patients underwent a thyroid nodule FNAB (results: 12 benign, one follicular neoplasm, three suspicious for malignancy, and one papillary thyroid cancer [PTC]), from which six underwent thyroidectomy; PTC was confirmed by surgical pathology for all cases (8.5% of all nodules observed). 31461359 2020
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. 31327063 2019
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE To find an appropriate management strategy for patients with T1bN0M0 PTC, the outcomes of active surveillance for T1bN0M0 to T1aN0M0 PTC were investigated and compared, and the outcomes of surgery for T1bN0M0 PTC were studied. 30560718 2019
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE Expression analysis of ANKRD26 and RET was performed for the tumor harboring ANKRD26-RET, for corresponding normal thyroid tissue and PTC tumors with representative genetic alterations (BRAFV600E, CCDC6-RET), complemented by a comparative search in the "UniProt" database. 31425920 2019
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE In conclusion, miR-146b-5p expression correlated with advanced PTC and promoted PTC development by targeting CCDC6 in vitro and in vivo; it could, therefore, serve as a promising target for PTC treatment. 30503553 2019
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE Preoperative cytology samples from 30 cases of histologically-proven PTC-TC and 30 classical PTC controls were selected for this study. 30648353 2019
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE The aim of this study was to evaluate the clinicopathologic characteristics of the MFV-PTC treated in the Yonsei University College of Medicine.Between September 2007 and July 2012, 18,697 patients with PTC were treated in our institution. 29489673 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE BACKGROUND The aim of this study was to investigate the expression of the BRAF V600E gene mutation and the RET/PTC gene rearrangement in the progression of papillary thyroid carcinoma (PTC) in 50 patients from Inner Mongolia. 30254191 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE CLN = central lymph node; PTC = papillary thyroid carcinoma; PTMC = papillary thyroid microcarcinoma. 30289307 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE FNA = fine-needle aspiration; GEC = gene expression classifier; NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features; PTC = papillary thyroid cancer; SFN = suspicious for follicular neoplasia. 30084677 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE Papillary thyroid carcinoma (PTC) generally shows an excellent prognosis except in cases with aggressive backgrounds or clinicopathological features. 29349484 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE β-cat = β-catenin 1; CI = confidence interval; PTC = papillary thyroid carcinoma; ROC = receiver operating characteristic. 29498921 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE AACE = American Association of Clinical Endocrinologists EFVPTC = encapsulated FVPTC FNA = fine-needle aspiration FVPTC = follicular variant of papillary thyroid carcinoma NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features PTC = papillary thyroid carcinoma. 28920749 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE Small papillary thyroid cancer (PTC) generally has an excellent prognosis. 27732329 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease CTD_human Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. 28030816 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE Microscopic examination of CMV-PTC revealed predominately cribriform and morular pattern of cancer cells with characteristic nuclear features of papillary thyroid carcinoma.Psammoma body is rare. 28314770 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE Comparing the cytological or, when performed, histological diagnoses with the results of FNAB-Tg, we found that in 24 cases of lymph node metastases from PTC (19 lymph nodes from patients at the first diagnoses and 5 lymph nodes from PTC patients in follow up) the mean level of Thyroglobulin was 1840.11 ng/ml; range: <0,2 to 11440 ng/ml. 28558632 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE Discovering the mechanism of PTC genesis and progression and finding new potential diagnostic biomarkers/therapeutic target genes of PTC are of great significance. 28673327 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE CCI = Charlson Comorbidity Index; CCR = California Cancer Registry; CI = confidence interval; DTC = differentiated thyroid cancer; FTC = follicular thyroid carcinoma; HCC = Hürthle cell carcinoma; IQR = interquartile range; mPTC = papillary thyroid micro-carcinoma; OR = odds ratio; OSPHD = Office of Statewide Health Planning and Development; PTC = papillary thyroid carcinoma. 28816539 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE These results highlight an important role of <i>miR-195</i> in the initiation and progression of PTC and implicate the potential application of <i>miR-195</i> in PTC target therapy. 28740507 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE FNA = fine-needle aspiration miRNA = micro RNA NGS = next-generation sequencing NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features NPV = negative predictive value PPV = positive predictive value PTC = papillary thyroid carcinoma RAI = radioactive iodine. 28534687 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE Although PTC-CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis.Cancer Cytopathol 2017;125:389-97.© 2017 American Cancer Society. 28374549 2017
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 Biomarker disease BEFREE The aims of the current study were to explore plasma lncRNAs as a novel biomarker panel for the diagnosis of non-131I-avid lung metastases of PTC and to investigate the plasma lncRNA expression levels associated with survival in PTC patients with lung metastases. 27997908 2016
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 FusionGene disease ORPHANET Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. 25407564 2015
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.600 GeneticVariation disease BEFREE The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. 24858900 2014