| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Moreover, the hBM-MSC-induced decrease in the signaling pathway of NADPH oxidase was accompanied by the decrease of the activated HSC number and liver fibrosis in a mouse model of CCl<sub>4</sub>-induced liver fibrosis. | 29861737 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | NADPH oxidase (Nox) variants Nox1, Nox2 and Nox4 are implicated in the progression of liver fibrosis. | 30036633 | 2018 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | However, there was a substantial increase in hepatocyte death and liver fibrosis in fructose-fed middle-aged mice deficient in hepatocyte-specific eIF2α phosphorylation because of diminished antioxidant capacity due to reduced expression of antioxidant enzymes (GPX1 and HO-1) and lower NADPH and glutathione levels, as well as a possible increase in ROS-induced damage from infiltrating NOX2-expressing leukocytes; all this led to a vicious cycle of hepatocyte death and leukocyte infiltration. | 28781602 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | NADPH oxidases (NOXs) are a predominant mediator of redox homeostasis in hepatic stellate cells (HSCs), and oxidative stress plays an important role in the pathogenesis of liver fibrosis. | 26347199 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | Moreover, accumulating evidence indicates that NADPH oxidases (NOXs), which play a critical role in the inflammatory response, may contribute to reactive oxygen species (ROS) production during liver fibrosis, being important players in HSC activation and hepatocyte apoptosis. | 26204504 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. | 23049784 | 2012 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Here we have further investigated the downstream effects of phagocytosis by studying NADPH oxidase activation and its link to procollagen alpha1 (I) and TGF-beta1 expression in an immortalized human stellate cell line and in several models of liver fibrosis. | 16496318 | 2006 |