Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.360 | AlteredExpression | disease | BEFREE | Furthermore, we demonstrate that reduced secretion of C-C motif chemokine ligand 2, as a result of post-transcriptional regulation of GNAI2 (G protein alpha inhibiting activity polypeptide 2) by miRNA-221-3p, mitigates liver fibrosis. | 30582979 | 2019 | ||||
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0.360 | Biomarker | disease | BEFREE | Our study demonstrates that splenic macrophages can promote hepatic macrophage secretion of CCL2, which in turn facilitates monocyte recruitment and the establishment of an M1-dominant hepatic macrophage phenotype, and thus increase the severity of liver fibrosis. | 30458454 | 2018 | ||||
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0.360 | Biomarker | disease | BEFREE | We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. | 28267084 | 2017 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Although serum CCL2 levels were associated with early liver fibrosis, rs12075 itself was not associated with HCV infection or the severity of liver disease in any of the cohorts. | 21156192 | 2011 | ||||
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0.360 | Biomarker | disease | CTD_human | Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. | 20697377 | 2010 | ||||
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0.360 | Biomarker | disease | BEFREE | In conclusion, blockade of MCP-1 after intramuscular transfer of the 7ND gene suppressed hepatic fibrosis, and this strategy may be a useful and feasible gene therapy against hepatic fibrosis. | 15492853 | 2004 | ||||
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0.360 | Biomarker | disease | BEFREE | Recent studies suggest that CCL2/monocyte chemoattractant protein-1 plays an important role in the fibrotic process, including liver fibrosis, pulmonary fibrosis, and scleroderma. | 12846061 | 2003 |