Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE In conclusion, our study demonstrated that IMI exposure induces liver fibrosis via activation of the TGF-β1/Smad signaling pathway in quails. 31835194 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE In conclusion, these findings indicated that Nano NiO induced hepatic fibrosis via TGF-β1-mediated Smad pathway activation, EMT occurrence, and ECM deposition. 31737983 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE Mechanistically, we demonstrated that high level of MFN2 inhibited TGF-β1/Smad signaling pathway, triggered downregulation of type I, type III, and type IV collagen, and antagonized the formation of factors associated with liver fibrosis. 31802713 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE NS5ATP9 inhibited liver fibrosis through TGFβ1/Smad3 and NF-κB signaling pathways. 31758498 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE The aim of this project was to develop a suitable rodent cell culture model for the investigation of key events involved in the development of liver fibrosis, specifically the responses to pathophysiological stimuli such as TGF-β1 and LPS-triggered inflammation. 31730938 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Macrophage MerTK promotes an ERK-TGFβ1 pathway that activates HSCs and induces liver fibrosis. 31839486 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Additionally, MSCs were stimulated in vitro with LF-associated factors, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and transforming growth factor-β1 (TGF-β1), to mimic the LF microenvironment. 31508820 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE As liver fibrosis is the consequence of hepatic stellate cell (HSC) activation, the questions were addressed whether alterations induced by high glucose concentration are directly related to TGFB1 effect, or other mechanisms are activated. 30109568 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Autophagy is a self-degrading process.Previously, we showed that insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) is a novel transforming growth factor β1 (TGFβ1)-interacting factor in liver fibrosis; the role of TGFβ1-mediated autophagy in hepatic stellate cells (HSCs) activation has been investigated. 31468266 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE However, TIM-4 interference in the KCs inhibited Akt1-mediated ROS production, resulting in the suppression of PINK1, Parkin and LC3-II/I activation and the reduction of TGF-β1 secretion during liver fibrosis. 31755616 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE <i>Dendropanax morbifera</i> Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways. 30906211 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE To avoid the impact of schistosomicidal activity of PZQ against liver fibrosis induced by S. japonicum infection, we established a mouse model of carbon tetrachloride (CCl<sub>4</sub> )-induced liver fibrosis for in vivo studies and used TGF-β1-stimulated human hepatic stellate cell line (LX-2) in addition to other fibroblast-like cell line (MES13) and fibroblast cell line (NIH3T3) in vitro. 31412137 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE Collectively, our results reveal that SEPT6 regulates various biological behaviors in HSCs through TGF-β1/Smad, mitogen-activated protein kinases and phosphatidylinositol-3-kinase/protein kinase B signaling pathways, thus promoting liver fibrosis. 30315255 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE These findings suggested that AKF-PD attenuated the progression of hepatic fibrosis by suppressing HSCs activation via the TGF-β1/Smad and MAPK signaling pathways, and therefore that AKF-PD may be suitable for use as a novel therapeutic agent against liver fibrosis. 31258636 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE The degree of liver fibrosis was suppressed by treatment with VA-coupled liposomal ROCK inhibitor, and the expression of α-SMA and TGF-β1 in liver tissues was also significantly suppressed. 30675748 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE In conclusion, our results demonstrate that MFA attenuated liver fibrosis and hepatic stellate cell activation by inhibiting the TGF-β1/Smad and NOX4/ROS signalling pathways. 30543783 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. 30723271 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin. 29864192 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Our results demonstrated that RCAN1.4 over-expression alleviates, whereas its knockdown exacerbates, TGF-β1-induced liver fibrosis <i>in vitro</i> in a CaN/NFAT3 signaling-dependent manner. 31285763 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy pathway. 31677501 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE These results clearly show that LQ ameliorated experimental liver fibrosis by acting on the TGF-β1/Smad and Hippo/YAP pathways, indicating that LQ has the potential for effective treatment of liver fibrosis. 31121384 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE Quantitative PCR verified that linc-SCRG1 increased along with liver fibrosis progression in human tissues and in activated LX2 cells induced by TGF-β1. 30226813 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE The accumulation of transforming growth factor beta 1 (TGF-β1) in liver fibrosis local microenvironment may play an essential role in the rapid cell death of implanted β2m-/Thy1+ BDHSCs. 30365941 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE We demonstrate that NV556 decreased liver fibrosis in both STAM and MCD in vivo models and decreased collagen production in TGFβ1-activated hepatic stellate cells in vitro. 31717385 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Characteristic features of liver fibrosis in 10% fructose-fed rats and EMT in 5 mM fructose-exposed BRL-3A cells with or without pterostilbene and the change of miR-34a/Sirt1/p53 and transforming growth factor-β1 (TGF-β1)/Smads signalling were examined. 30632134 2019