Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 AlteredExpression disease BEFREE This study showed that the direct and indirect effect of IL-37 on macrophages could reduce the hepatic TNF-α expression, and also modulate IL-1β/IL-12 and IL-10/IL-1Ra expression to suppress the hepatic IFN-γ expression, thus suppressing the development of T cell-dependent liver injury such as autoimmune hepatitis. 30735937 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 GeneticVariation disease BEFREE We identified a significant association between IL-10 -1082/-819 and TGF-β +869/+915 genotypes and haplotypes with autoimmune hepatitis in Iranians. 30143451 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 AlteredExpression disease BEFREE There were significantly fewer CD4⁺CD25⁺ T cells in the AIH group, and interleukin 6 (IL-6) and IL-10 levels were significantly decreased compared to the HC group (p<0.05). 31422415 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 GeneticVariation disease BEFREE We performed a meta-analysis to assess the association between three IL10 promoter polymorphisms (rs1800896, rs1800871, and rs1800872) and the risk of autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. 29694797 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 AlteredExpression disease BEFREE Also, the serum levels of IL-17A and IL-22 were correlated positively with liver injury (ALT/AST), whereas the serum levels of IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH patients. 30050955 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 Biomarker disease BEFREE In AIH, Gal9(pos) T-regs were fewer and contained less FOXP3(pos), IL-10(pos), and transforming growth factor β(pos) and more IFNγ(pos) and IL-17(pos) cells than HS. siRNA treatment of Gal-9(pos) T-regs drastically reduced T-reg ability to suppress CD4(pos) CD25(neg) and Tim-3(pos) cell proliferation in AIH and HS. 22371007 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 Biomarker disease CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.370 GeneticVariation disease BEFREE The aim of this study was to investigate, for the first time, 2 members of the interleukin-1 (IL-1) family (IL-1B and IL-1RN), 3 polymorphic sites in the interleukin-10 (IL-10) gene promoter (positions -1082, -819, and -592), and 2 polymorphisms in the tumor necrosis factor-alpha (TNF-alpha) promoter (positions -308 and -238) in type 1 AIH. 10498633 1999
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 AlteredExpression disease BEFREE This study showed that the direct and indirect effect of IL-37 on macrophages could reduce the hepatic TNF-α expression, and also modulate IL-1β/IL-12 and IL-10/IL-1Ra expression to suppress the hepatic IFN-γ expression, thus suppressing the development of T cell-dependent liver injury such as autoimmune hepatitis. 30735937 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 GeneticVariation disease BEFREE G/T alleles of IL-2 at -330 (rs2069762) and A/T alleles on UTR +5644 position at IFN-γ and their subsequent haplotypes, did not show significant association with AIH. 29288086 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 AlteredExpression disease BEFREE Exposure to ISDs contains IFN-γ and PD-1 expression in AIH, where control over CD4<sup>+</sup> CD25<sup>-</sup> cell proliferation is also noted upon exposure to MPA. 28257599 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 Biomarker disease BEFREE In AIH, Gal9(pos) T-regs were fewer and contained less FOXP3(pos), IL-10(pos), and transforming growth factor β(pos) and more IFNγ(pos) and IL-17(pos) cells than HS. siRNA treatment of Gal-9(pos) T-regs drastically reduced T-reg ability to suppress CD4(pos) CD25(neg) and Tim-3(pos) cell proliferation in AIH and HS. 22371007 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 Biomarker disease CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 AlteredExpression disease BEFREE The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis. 20884299 2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.360 AlteredExpression disease BEFREE IL-1 beta and interferon gamma mRNA showed increased expression in cirrhotics with autoimmune chronic active hepatitis compared with those with primary biliary cirrhosis. 8076766 1994
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 AlteredExpression disease BEFREE Also, the serum levels of IL-33 in AIH patients were correlated positively with proinflammatory cytokine levels (IL-17A and IL-4). 30034292 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 GeneticVariation disease BEFREE This study revealed the presence of an association between IL-4 -590 TT genotype and T alleles with increased AIH risk in pediatric patients, also assess its severity as they were detected with Child Plugh scores B and C. 29396050 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 GeneticVariation disease BEFREE This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions. 26735262 2016
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 GeneticVariation disease BEFREE Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. 26693492 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 Biomarker disease CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906 2011
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.350 AlteredExpression disease BEFREE Simultaneous expression of Th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children. 15301856 2004
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.340 GeneticVariation disease BEFREE G/T alleles of IL-2 at -330 (rs2069762) and A/T alleles on UTR +5644 position at IFN-γ and their subsequent haplotypes, did not show significant association with AIH. 29288086 2018
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.340 Biomarker disease BEFREE Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis. 29323192 2018
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.340 Biomarker disease BEFREE Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy. 28700730 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.340 Biomarker disease CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906 2011