Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. 16376453 2006
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis. 30170377 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE All isolates were in vitro evaluated for their cytotoxic activity against seven lung cancer cell lines, in addition to antimicrobial activity for eight bacteria, scavenging potential using ABTS<sup>·+</sup> and DPPH test, and anti-inflammatory activity for Cox-1 and Cox-2 which had not previously been tested for crinane-type alkaloids with the cleavage between C-1 and C-13. 30114468 2018
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Although preclinical studies have suggested that aspirin and Cox-2 inhibitors may influence the progression of lung cancer, the molecular mechanisms of these protective effects in this tumor type has not been fully elucidated. 17342322 2007
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE BPA induced COX-2 expression via nuclear translocation of NF-κB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells. 28709031 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer. 26624903 2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX‑2, has been observed in lung cancer tissue. 24337484 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells. 28173828 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Further, while COX-2 itself is known to be inducible in inflammation, COX-2 expression levels correlated well with the capabilities of these clones for not only in vitro motility and invasion but also in vivo metastasis, and COX-2 inhibitors were shown for the first time to reduce lung cancer metastasis in vivo. 11464289 2001
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE However, the regulatory mechanism underlying COX-2 overexpression in lung cancer is not fully understood. 21678473 2011
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone. 7706493 1995
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin‑mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro. 26600514 2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. 28150906 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 23943857 2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. 30591531 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. 31231223 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Interestingly, COX-2 is overexpressed in numerous cancers, including lung cancer. 25047043 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE It has been reported that inhibition of COX-2 beside traditional effects of NSAIDs, reduces the risk of colorectal, breast and lung cancers and also slow the progress of Alzheimer's disease.Zarghi et al. reported 8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 102) as a novel compound with similar IC50 to celecoxib besides improved selectivity index (COX-1/COX-2 inhibitory potency) in comparison with celecoxib. 28979299 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer. 26744864 2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Moreover, downregulation of COX-2/PGE2 and MIG-7 significantly prolonged the overall and disease-free survival of lung cancer-bearing mice. 25004182 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Our findings imply that a COX-2 inhibitor might improve the prognosis of patients with lung cancer through the reduction of G-CSF or GM-CSF. 12708493 2003
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Our study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2-mediated diseases such as lung cancer. 25175164 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE p38 MAPK, ERK, and COX-2 activation are novel mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer. 22696230 2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. 25465874 2015
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Since lung cancer patients were recruited mostly among smokers, who also have been found to exhibit significantly higher infection rate of Helicobacter pylori (HP) infection than non-smokers and, as since the HP-infected subjects show enhanced plasma levels of gastrin, we decided 1) to compare the seroprevalence of HP and the expression of its cytotoxin, CagA, in lung cancer patients with those in the age- and gender-matched controls without cancer: 2) to determine the gene expression for gastrin and its receptors (CCKB-R) in lung cancer, 3) to assess the gastrin levels in plasma bronchial lavage and in tumor tissue and 4) to examine the expression of cyclooxygenase (COX)-1 and COX-2 in cancer tissue resection margin and intact bronchial mucosa. 11208460 2001