Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 GeneticVariation disease BEFREE SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study). 31158500 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE All of these results suggested that the lncRNA FER1L4 suppressed cell proliferation and metastasis by inhibiting the PI3K/Akt signaling pathway in lung cancer. 31115514 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Co-mutations in <i>TP53</i> and the <i>PI3K/AKT/mTOR</i> pathway confer additional resistance to anti-HER2 treatments in lung cancer. 31748336 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer. 31452780 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE Consistently, DOK7V1 overexpression in lung cancer cells suppressed the phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathways, but activated the focal adhesion kinase (FAK)/paxillin signaling pathway. 30431081 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE Finally, we identified that the PI3K-AKT and epilthelial-mesenchymal transition (EMT) signaling pathways were inhibited by miR-3666 overexpression in lung cancer cells. 30481052 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Furthermore, cotreatment with sesamin and CAY10404 markedly reduced the levels of phosphorylated protein kinase B (pAkt) and phosoinositide 3 kinase (PI3K) in three lung cancer cell lines. 30365050 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss. 30825612 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Therefore, targeting the PI3K pathway may be a potential therapeutic strategy that prevents the structural skeletal damage associated with bone metastasis of lung cancer. 30896825 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE The phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) signaling has been shown to contribute to tumorigenesis, tumor progression, and resistance to therapy in most human cancer types, including lung cancer. 31262325 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Mutations in EGFR, KRAS, BRAF, and PIK3CA genes are widely analyzed in solid tumors such as lung cancer, colorectal cancer, breast cancer, and melanoma. 29304903 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE MicroRNA-374b accelerates the development of lung cancer through downregulating PTEN expression via activating PI3K/Akt pathway. 30779080 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 GeneticVariation disease BEFREE We performed NF1 sequencing using next generation sequencing (NGS) in 154 lung adenocarcinoma surgical specimens with known KRAS, EGFR, TP53, BRAF, HER2, and PIK3CA status, to evaluate the molecular and clinical specificities of NF1-mutated lung cancers. 31199580 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Our studies suggest that miR-183-5p may function as a tumor suppressor in lung cancer via the miR-183-5p/PIK3CA regulatory axis and identify a potentially effective therapeutic strategy for lung cancer. 30528264 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE TP53, EGFR and PIK3CA gene variations observed as prominent biomarkers in breast and lung cancer by plasma cell-free DNA genomic testing. 31100334 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. 30787353 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Additionally, Aclidinium Bromide suppressed the PI3K/AKT signaling pathway in lung cancer A549 cells. 31128006 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE To date, PI3K inhibitors have not been approved for lung cancer. 31337981 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE Compared with those in the control group, expression of PI3K and Akt in the lung cancer cells H1299 after EGCG treatment showed no significant differences (p>0.05), while expression levels of p-PI3K and p-Akt were significantly reduced (p<0.05). 30058690 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation. 29961813 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Moreover, MCMs and PHGDH can be poor prognostic factors for lung cancer. 29888431 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling. 29516506 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 AlteredExpression disease BEFREE We demonstrated that regulation of JNK/ P38/PI3K by TGF-β1 led to down expression of NMII-A which promoted EMT and lung cancer metastasis. 28782471 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE The effect of paclitaxel combined with lobaplatin on the sensitivity of lung cancer cell line NCI-H446 through influencing the phosphatidylinositol 3-kinase (PI3K)/Akt pathway was investigated. 29616103 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.600 Biomarker disease BEFREE Effect of miR-21 on Apoptosis in Lung Cancer Cell Through Inhibiting the PI3K/ Akt/NF-κB Signaling Pathway in Vitro and in Vivo. 29669316 2018