|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
OCT4&SOX2-specific cytotoxic T lymphocytes plus programmed cell death protein 1 inhibitor presented with synergistic effect on killing lung cancer stem-like cells in vitro and treating drug-resistant lung cancer mice in vivo.
|
30382588 |
2019 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
OCT4 over-expression in lung cancer was strongly related to poorer clinicopathological features and worse survival outcomes, which suggests that OCT4 could be a valuable prognostic marker in lung cancer.
|
30854966 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Higher levels of ΔNp63α were observed in the lung cancer tissues of smokers than in those of non-smokers, whereas ΔNp63α was positively correlated with CD133 and Oct4 expression in lung cancer tissues.
|
31367260 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pluripotent (OCT4, NANOG) and lung cancer stem cell marker (CD166) genes were studied in these cells.
|
31582014 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Egr1, osteopontin (OPN) and Oct4 expression in human lung cancer was determined by performing immunohistochemistry.
|
31399076 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study suggested that bFGF/FGFR signalling plays an important role in maintaining lung cancer stem cell characteristics and regulating expression of cancer stem cell marker of OCT-4.
|
31282010 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our recent study reported that multidrug-resistant (MDR) human A549 lung cancer cells (A549RT-eto) with the elevated expression of NF-κB showed epithelial-mesenchymal transition (EMT), increasing spheroid formation and elevating the expression levels of stemness-related factors, including Oct4, Nanog, Sox2, Bmi1, and Klf4.
|
30606669 |
2019 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical results confirm that concordantly low Rab37, low SFRP1, and high Oct4 stemness protein expression profile can be used as a biomarker to predict poor prognosis in lung cancer patients.
|
30158579 |
2018 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression correlations between Oct4 and lncRNAs were investigated in 124 lung cancer patients using qRT-PCR analysis.
|
28615056 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, immunohistochemical staining indicated that there was an increased number of octamer-binding protein 4 (Oct-4)-positive cells present in mouse tissues with advanced stages of the disease compared with tissues without lung cancer or at the initial stages of disease.
|
29142598 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Such findings were proved in different lung cancer cell lines (H460, H23, and H292) and it was found that CSC markers (CD133 and ALDH1A1), stem cell-associated transcription factors (Oct4, Nanog, and Sox-2), and the ability to form tumor spheroid were dramatically suppressed by zinc treatments.
|
28122729 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.
|
26996130 |
2016 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
Through an integrative approach combining our Oct4 chromatin-immunoprecipitation sequencing and ENCODE datasets, we identified the genome-wide binding regions of Oct4 in lung cancer at promoter and enhancer of numerous genes involved in critical pathways which promote tumorigenesis.
|
25609695 |
2015 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study indicated that Oct4 affected the cell biology of lung cancer cells in vitro through promoting lung cancer cell metastasis via EMT; in addition, the results suggested that the association and degradation of the β‑catenin/E‑cadherin complex was regulated by Oct4 during the process of EMT.
|
25420671 |
2015 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With the exception of OCT4, other markers Bmi1, CD133, CD44, Sox2, Nanog and Msi2 mRNA and protein were abundantly expressed in lung cancer.
|
23683495 |
2013 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real-time polymerase chain reaction and western blotting were used to detect the mRNA and protein expression profiles of Oct4 and KPNA2 in lung cancer cell lines.
|
24070213 |
2013 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our previous study demonstrated that the lung cancer stem-like cells isolated from A549 tumor spheres, which were cultured in serum-free conditioned medium, had stronger proliferation and self-renewal abilities, and expressed higher levels of the stem cell markers Sox2 and Oct4 as compared to A549 adherent cells.
|
24101104 |
2013 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
We, therefore, confirmed that miR-145 can impair the proliferation of human lung adenocarcinoma-initiating cells by targeting OCT4 and leads to inhibition of lung cancer development.
|
21479367 |
2011 |
|
POU5F1P4
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provides strong evidence that canonical Wnt signaling plays an important role in lung cancer stem cell properties, and it also regulates OCT-4, a lung cancer stem cell marker.
|
20074550 |
2010 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer.
|
18612434 |
2008 |