Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE Mechanistically, we uncovered that autophagy was induced upon loss of <i>circHIPK3</i> via the <i>MIR124-3p</i>-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines (A549 and H838). 31232177 2020
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE We developed a mouse model for <i>Lkb1</i>-deficient lung cancer with conditional deletion of essential autophagy gene <i>Atg7</i> to test whether autophagy compensates for LKB1 loss for tumor cells to survive energy crises. 30692209 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss. 30825612 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 AlteredExpression disease BEFREE Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells. 31333780 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Co-occurring genomic alterations, particularly in tumour suppressor genes such as TP53 and LKB1 (also known as STK11), have emerged as core determinants of the molecular and clinical heterogeneity of oncogene-driven lung cancer subgroups through their effects on both tumour cell-intrinsic and non-cell-autonomous cancer hallmarks. 31406302 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers. 30626603 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE Inactivated mutations of LKB1, observed in 20-30% of nonsmall cell lung cancers (NSCLC), contribute significantly to lung cancer malignancy progression. 31217475 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE The aim of this review is to discuss interactions of LKB1 with the tumor microenvironment and the potential applications of this knowledge in predicting response to treatment in lung cancer. 30995715 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE In vivo study also showed that Shh signaling pathway was involved in the modulation of LKB1 on the metastasis and angiogenesis of lung cancer. 30784288 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. 31285420 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE SIGNIFICANCE: Oncogenic <i>KRAS</i>-mutant lung cancers remain treatment-refractory and are resistant to ICB in the setting of LKB1 loss. 30297358 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Although loss-of-function mutations involving the tumor suppressor gene, <i><i>STK11</i> (LKB1)</i> are important in lung cancer progression, <i> 31697874 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Targeted therapies for LKB1-inactivated lung cancer are currently unavailable. 30423141 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Our in vivo study also showed that LKB1 inhibited lung cancer growth in vivo and modulated Shh signaling pathway. 29573522 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Our study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer. 29249655 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. 29963200 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 GeneticVariation disease BEFREE Moreover, mutations and misregulation of LKB1 have been reported to occur in most types of tumors and are among the most common aberrations in lung cancer. 29540834 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. 30297789 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Liver kinase B1 (LKB1) as a tumor suppression gene that is associated with various kinds of cancers, including lung cancer. 30033530 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 AlteredExpression disease BEFREE PLAG1-mediated GDH1 upregulation promotes LKB1-deficient lung cancer anoikis resistance. 29305497 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE In addition, exosomes isolated from H460 cells with stable restoration of LKB1 had much higher ability in stimulating lung cancer cell migration than did those from H460 cells lacking LKB1. 29138862 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE We used a mouse lung cancer model with metastasis driven by conditionally activated Kras and concurrent tumor suppressor Lkb1 loss (Kras<sup>G12D</sup>/ Lkb1<sup>-/-</sup> model) and a similar model of lung cancer that does not metastasize, driven by conditionally activated Kras alone (Kras<sup>G12D</sup> model). 29909489 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Further, CP alone or in combination with rapamycin strongly inhibited the in vitro and in vivo growth of tumors harboring mutations in KEAP1 or both KEAP1 and LKB1 that are frequently observed in lung cancer. 28504720 2017
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 AlteredExpression disease BEFREE Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. 28598439 2017
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.600 Biomarker disease BEFREE Our study also provides new evidence to support the critical role of liver kinase B1 in the pathogenesis of human papillomavirus-related lung cancer and suggests novel therapeutic targets. 28720067 2017