Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE However, whether or not VEGF is indeed critical for the pathogenesis of subretinal neovascularization (SRN) in adulthood, which is a serious complication of age-related macular degeneration, has to be further investigated. 10849558 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has been strongly implicated in the development of choroidal neovascularization found in age-related macular degeneration. 10880384 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. 11748590 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Since the secretion of VEGF by HRPE is regulated by MAP kinase pathways, MAP kinase inhibitors may have potential use as therapeutic agents for CNV in AMD. 14566975 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE On the other hand, this paracrine relation and other physiological functions of VEGFs may be endangered by therapeutic VEGF inhibition, as is currently used in several clinical trials in DR and AMD. 12597922 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration. 12778165 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Furthermore, VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration. 15294883 2004
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease CTD_human Aberrant retinal expression of vascular endothelial growth factor (VEGF) leading to neovascularization is a central feature of age-related macular degeneration and diabetic retinopathy, two leading causes of vision loss. 15788408 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression disease BEFREE Expression of VEGF and angiopoietins in subfoveal membranes from patients with age-related macular degeneration. 15808152 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease LHGDN This is the most extensive analysis of the VEGF gene in AMD, demonstrating a clear association with the exudative form of disease, thereby creating the possibility for predictive testing. 16940309 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Controlling the balance of VEGF(xxx) to VEGF(xxx) isoforms may therefore be therapeutically valuable in the treatment of proliferative eye diseases such as diabetic retinopathy and age related macular degeneration. 16735996 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE This is the most extensive analysis of the VEGF gene in AMD, demonstrating a clear association with the exudative form of disease, thereby creating the possibility for predictive testing. 16940309 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease LHGDN Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. 16384981 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. 16384981 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease LHGDN We undertook a case-control association study to investigate the VEGF-A gene, a known angiogenic gene that has previously been associated with AMD. 18079689 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE We undertook a case-control association study to investigate the VEGF-A gene, a known angiogenic gene that has previously been associated with AMD. 18079689 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease LHGDN Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. 18378209 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE AMD RESULTS: Of 4228 participants at risk for incident early and late AMD for whom blood specimens were available for VEGF genotyping, incident early AMD developed in 514 and incident late AMD developed in 89 (35 dry and 54 wet) after a mean follow-up of 7.4 years. 18708255 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE Both VEGF +936 C/T and CFH Y402H polymorphisms are dependently associated with wet AMD in the Taiwan Chinese population. 18378209 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from age-related macular degeneration, are premised on gene silencing by means of intracellular RNA interference (RNAi). 18368052 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Although inhibition of vascular endothelial growth factor with ranibizumab has demonstrated efficacy and safety in the treatment of neovascular AMD, novel treatments targeting different mechanisms that play a role in CNV development currently are being investigated. 19800536 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF-A) is a major pathogenic factor and a therapeutic target for age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity. 19768732 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) is important in pathological neovascularization, which is a key component of diseases such as the wet form of age-related macular degeneration, proliferative diabetic retinopathy and cancer. 18633446 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms. 19761764 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE The 29 VEGFA and VEGFR-2 SNPs analyzed in our cohort demonstrated no significant association with neovascular AMD. 20019880 2009