Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE 1093 patients with exudative AMD and 396 controls have been recruited and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and T280M of the CX3CR1 gene. 21621535 2011
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Age-related macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision loss in the elderly, is associated with polymorphisms in the LOC387715/ARMS2 and HTRA1 genes on 10q26. 18535016 2008
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most likely to exhibit elevated CEP markers. 19202148 2009
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most likely to exhibit elevated CEP markers. 20238042 2010
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease BEFREE ARMS2 was mainly distributed in the cytosol, not in the mitochondrial outer membrane as previously reported, suggesting that ARMS2 may not confer risk to AMD through the mitochondrial pathway. 19255159 2009
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease BEFREE ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. 19696174 2010
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 AlteredExpression disease BEFREE ARMS2 and HTRA1 mRNA levels did not show a significant difference in expression among the control (young and elderly) and AMD retinas. 20664794 2010
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. 21122828 2011
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE ARMS2 rs10490924 was also significantly associated with the risk allele T found at a frequency of 0.5 in AMD and 0.15 in controls (p < 0.017, χ(2) test). 23362846 2013
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE R38X variant of ARMS2 seems to be protective from wet ARMD. 22293892 2012
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988 2016
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease LHGDN A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population. 17194541 2007
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE A risk allele of ARMS2 A69S was more frequently seen in patients with bilateral AMD (P = .0270) than in those with unilateral AMD. 22809783 2012
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Addition of a genetic analysis for one of the most prevalent amino acid substitutions in the age-related maculopathy susceptibility 2 gene linked to AMD, Ala(69)→Ser, did not improve the statistical model. 26187344 2015
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with exudative AMD (P = 0.011), but not with PCV (P = 0.077). 22491416 2012
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular AMD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011). 24865191 2014
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease BEFREE After adjusting for age, sex, body mass index, smoking status, age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) genotypes, and other factors, mean IMT was associated with the 10-year incidence of early AMD (odds ratio [OR] per 0.1 mm IMT, 1.11; 95% confidence interval [CI], 1.00-1.21; P = 0.03) and late AMD (OR per 0.1 mm IMT, 1.27; CI, 1.10-1.47; P = 0.001). 23399375 2013
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease BEFREE After adjustment for AMD, age and gender, EMD were neither associated with CFH (p=0.11) nor with ARMS2 (p=0.45) genotypes. 26614632 2016
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE After multivariate adjustment, CFH Y402H and ARMS2 A69S polymorphisms were associated with very high risk for exudative AMD (OR = 6.21 and OR = 11.7, respectively, p < 0.0001). 24362810 2014
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE After ranibizumab treatment, AMD patients without risk alleles in the CFH and ARMS2 genes (4.8%) demonstrated a mean VA improvement of 10 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, whereas no VA improvement was observed in AMD patients with 4 CFH and ARMS2 risk alleles (6.9%; P = 0.014). 22840423 2012
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Age and the T allele of ARMS2 A69S are the risk factors requiring retreatments, leading to poor visual change in eyes with exudative AMD following the initial 3-monthly IVR. 29045945 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 Biomarker disease BEFREE Age, race/ethnicity, current smoking, hyperopia, and AMD-susceptibility genotypes Complement Factor H (CFH) RS1061170 and Age Related Maculopathy Susceptibility 2 (ARMS2) RS3793917 were independently associated with incident early AMD in multivariable models for the combined sample. 26896123 2016
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Although the closely linked genome-wide association studies ARMS2/HTRA1 genes, located at the chromosome 10q26 locus, are strongly associated with the risk of AMD, their downstream targets are unknown. 24497574 2014
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Among different genotype combinations ARMS2-CFH and CFH-C3 combinations have the most significant levels of synergism and C3-CFI combination has the most significant level of antagonism in AMD patients. 29087762 2018